Gene interactions and pathways from curated databases and text-mining

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AKT1 — CDKN1A

Pathways - manually collected, often from reviews:

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

Text-mined interactions from Literome

Mitsuuchi et al., Cancer Res 2000 (Ovarian Neoplasms) : In addition, overexpression of wild-type or constitutively active AKT in A2780 cells sustained the regulation of p21 induction or increased the level of p21 expression, respectively
Lawlor et al., Mol Cell Biol 2000 : Here we show that IGF-I promotes muscle cell survival through Akt mediated induction of the cyclin dependent kinase inhibitor p21
Zhou et al., Nat Cell Biol 2001 (Adenocarcinoma...) : Our results indicate that HER-2/neu induces cytoplasmic localization of p21Cip1/WAF1 through activation of Akt to promote cell growth, which may have implications for the oncogenic activity of HER-2/neu and Akt
Pavelić et al., J Mol Med (Berl) 2001 (Body Weight...) : In vitro tissue culture studies showed that finely ground clinoptilolite inhibits protein kinase B ( c-Akt ), induces expression of p21WAF1/CIP1 and p27KIP1 tumor suppressor proteins, and blocks cell growth in several cancer cell lines
Schönherr et al., J Biol Chem 2001 : Involvement of Akt/protein kinase B in up-regulation of p21 ( WAF1/CIP1 ) but not p27 ( KIP1 ) ... Overexpression of dominant negative Akt inhibited the decorin mediated induction of p21 and cyclin A, but had no effect on p27
Li et al., J Biol Chem 2002 : AKT/PKB phosphorylation of p21Cip/WAF1 enhances protein stability of p21Cip/WAF1 and promotes cell survival
Vancurova et al., J Virol 2002 (Laryngeal Neoplasms...) : Increased NF-kappaB activity and cytoplasmic accumulation of p21 ( CIP1/WAF1 ) might counteract death promoting effects elicited by overexpressed PTEN and reduced activation of Akt and STAT3 previously noted in these tissues
Rössig et al., J Biol Chem 2002 : Signaling via the phosphoinositide 3-kinase (PI3K)/AKT pathway is crucial for the regulation of endothelial cell ( EC ) proliferation and survival, which involves the AKT dependent phosphorylation of the DNA repair protein p21 ( Cip1 ) at Thr-145
Hiromura et al., Kidney Int 2002 : Our results also showed that the CDK-inhibitor p21 was increased by insulin and that p21 up-regulation was PI3-kinase/Akt pathway dependent
Schönherr et al., Ann N Y Acad Sci 2002 : Induction of dominan negative Akt by a replication-deficient adenovirus blocked p21 and cyclin A synthesis, but had no effect on p27
Héliez et al., Oncogene 2003 (Neoplasms) : This cytoplasmic accumulation of p21 resulted from an AKT dependent p21 phosphorylation leading to an association of p21 with 14-3-3 ... Furthermore, the cytoplasmic p21 accumulation observed in PTX treated cells was inhibited by LY 294002, a specific PI-3 kinase inhibitor or by the expression of a dominant negative AKT mutant
Rahmani et al., Oncogene 2003 (Leukemia, Myelogenous, Chronic, BCR-ABL Positive) : Inhibition of PI-3 kinase sensitizes human leukemic cells to histone deacetylase inhibitor mediated apoptosis through p44/42 MAP kinase inactivation and abrogation of p21 ( CIP1/WAF1 ) induction rather than AKT inhibition
Comalada et al., Eur J Immunol 2004 : PI-3K inhibitors also block growth factor dependent expression of p21 ( Waf1 ) and the activation of Akt
Kokkinakis et al., J Neuropathol Exp Neurol 2004 (Cell Transformation, Neoplastic) : Western blot analyses demonstrated that MNU exposure caused progressive reduction of p21 protein levels, an increase of Rb phosphorylation, activation of AKT and CDK2, and upregulation of FGF receptors
Rattan et al., J Biol Chem 2005 (Neoplasms, Experimental) : Moreover, constitutive active AMPK arrested the cells in S-phase by inducing the expression of p21 , p27, and p53 proteins and inhibiting Akt phosphorylation, suggesting the involvement of AMPK
Lu et al., Int J Oncol 2006 (Prostatic Neoplasms) : PI3K-Akt signaling is involved in the regulation of p21 ( WAF/CIP ) expression and androgen independent growth in prostate cancer cells
Hauck et al., Circ Res 2007 (Hypertrophy) : Lovastatin also stimulates protein kinase B/Akt kinase activity, and Akt dependent phosphorylation forces p21 in the cytoplasm, where it inhibits Rho-kinases contributing to the suppression of cardiomyocyte hypertrophy
Xia et al., J Biol Chem 2007 (Neoplasms) : Collectively, these findings demonstrate that p21 ( RAS ), through its downstream effector PI3K, induces PKCdelta expression and that this increase in PKCdelta activity, acting through Akt , is required for cell survival
Harms et al., J Neurosci 2007 : Phosphatidylinositol 3-Akt-kinase dependent phosphorylation of p21 ( Waf1/Cip1 ) as a novel mechanism of neuroprotection by glucocorticoids
Wu et al., Sheng Wu Gong Cheng Xue Bao 2007 : [ The effect of protein kinase B on the expression and location of p21 in early development of mouse fertilized eggs ] ... To investigate the effect of Protein kinase B on the expression and location of p21 in mouse early development
Chiang et al., Mol Cancer Ther 2007 : Examination of the Akt/mammalian target of rapamycin (mTOR) signaling revealed that this signaling was only transiently inhibited by low doses of luteolin, which suggested that the inability to cause sustained Akt/mTOR inhibition may contribute to p21 induction and provide a survival advantage to HER2 overexpressing cancer cells
Wang et al., PloS one 2007 : Furthermore, we show here a novel mechanism for NRP-1-specific control of the anti-apoptotic pathway in EC through involvement of the NRP-1 interacting protein ( NIP/GIPC ) in the activation of PI-3K/Akt and subsequent inactivation of p53 pathways and FoxOs, as well as activation of p21
Park et al., Int J Radiat Oncol Biol Phys 2008 (Carcinoma, Non-Small-Cell Lung...) : Combination of PTEN and gamma ionizing radiation enhances cell death and G ( 2 ) /M arrest through regulation of AKT activity and p21 induction in non-small-cell lung cancer cells
Heo et al., Growth Factors 2008 : Moreover, TGF-alpha increased cyclin D/CDK 4 and cyclin E/CDK 2 levels, while decreasing p21cip1/waf1 and p27kip1, which were blocked by the inhibition of Akt , mTOR and Notch
Festuccia et al., Endocr Relat Cancer 2009 (Disease Models, Animal...) : In vivo, azacitidine ( 0.8 mg/kg i.p. ) reduced tumor proliferation and induced apoptosis in both xenografts upmodulating the expression of p16INKA, Bax, Bak, p21/WAF1 , and p27/KIP1, and inhibiting the activation of Akt activity and the expression of cyclin D1, Bcl-2, and Bcl-XL
Shabbeer et al., Cancer Biol Ther 2009 (Breast Neoplasms...) : Molecular changes induced in PCa cells are : in DU-145 cells : downregulation of mutant p53, and in PC-3 cells upregulation of p21 and inhibition of TGFbeta induced phosphorylation of Akt
Guan et al., J Invest Dermatol 2009 : However, neither Nckalpha nor Nckbeta was required for the activation of the PDGF receptor, p21 activated protein kinase ( Pak1 ), AKT , extracellular signal regulated kinase ( ERK ) 1/2, or p38MAP by PDGF-BB
Lee et al., Clin Cancer Res 2009 (Mammary Neoplasms, Experimental) : Mixed tocopherols increased the expression of p21 , p27, caspase-3, and peroxisome proliferator activated receptor-gamma, and inhibited AKT and estrogen signaling in mammary tumors
Lee et al., Mol Cells 2009 : Lf ( Fe ( 3+ ) ) immediately induced Akt phosphorylation at Ser473, which subsequently induced the phosphorylation of two G1-checkpoint Cdk inhibitors, p21 ( Cip/WAF1 ) and p27 ( kip1 )
Suh et al., Biochem Biophys Res Commun 2009 : Here, we demonstrate that the PP2Cgamma induced degradation of p21 ( Cip1/WAF1 ) is mediated by Akt signaling
Kim et al., Phytomedicine 2010 (Breast Neoplasms) : Finally, adenoviral constitutively active-Akt ( Ad-CA-Akt ) overexpression regulated the up-regulation of cyclin B1 and the down-regulation of p21
Vaid et al., Carcinogenesis 2010 (Cell Transformation, Neoplastic...) : Western blot analysis revealed that honokiol : ( i ) inhibited the levels of cyclins D1, D2 and E and associated cyclin dependent kinases (CDKs)2, CDK4 and CDK6, ( ii ) upregulated Cip/p21 and Kip/p27 and ( iii ) inhibited the levels of phosphatidylinositol 3-kinase and the phosphorylation of Akt at Ser ( 473 ) in UVB induced skin tumors
Li et al., Biomed Environ Sci 2010 : CagA ( + ) H. pylori induces Akt1 phosphorylation and inhibits transcription of p21 ( WAF1/CIP1 ) and p27 ( KIP1 ) via PI3K/Akt1 pathway ... Activation of PI3K/Akt1 pathway and subsequent negative regulation of p21 ( WAF1/CIP1 ) and p27 ( KIP1 ) expression might be involved in CagA associated carcinogenesis
Moon et al., Cell Mol Life Sci 2011 : Akt mediated phosphorylation of p21 and protection of apoptosis are completely abolished by inhibitors of PI3K and Akt
Yohn et al., BMC urology 2011 (Carcinoma, Transitional Cell...) : PI3-kinase and AKT cause an upregulation of p21 by suppressing GSK-3ß activity and activating mTOR in both cultured human urothelial carcinoma cells and mouse urothelial cells in vivo
Christgen et al., Lab Invest 2012 (Breast Neoplasms...) : These genes included CDKN1A , MDM2 and PHLDA3, a recently described p53-inducible inhibitor of AKT
Yajima et al., J Dermatol Sci 2012 (Melanoma) : Proliferation of GNG2 overexpressed SK-Mel28 human malignant melanoma cells was suppressed with decreased c-SRC and AKT activities and increased p21 ( Cip/WAF1 ) expression level in vitro
Chou et al., Br J Pharmacol 2013 : Overexpression of AKT1 , but not of AKT2, induced p21/p27 phosphorylation and increased cytosolic p21/p27 levels, as did homocysteine treatment
Rokudai et al., Proc Natl Acad Sci U S A 2013 (Leukemia, Promyelocytic, Acute) : As a result of PML mediated suppression of Akt , the increased PML-MOZ interaction enhances p21 expression and induces p53 dependent premature senescence upon forced PML expression
De Santi et al., Anticancer Res 2013 (Breast Neoplasms) : Background/Aim : The indole-3-carbinol cyclic tetrameric derivative ( CTet ) inhibits breast cancer cell proliferation by endoplasmic reticulum stress and autophagy related cell death induction, AKT/PKB ( protein kinase B ) activity inhibition and p53 independent overexpression of cyclin dependent kinase inhibitor-1A ( p21/CDKN1A )
Cordero-Herrera et al., Nutr Cancer 2013 : Exposure of SW480 cells to ECG also led to apoptosis as determined by time dependent changes in caspase-3 activity, MAPKs [ extracellular regulated kinase (ERK), p38, and c-jun amino-terminal kinase ( JNK ) ], p21 and p53 activation, and AKT inhibition
Genot et al., Oncogene 1998 : In contrast, p21ras signals are unable to induce Akt/PKB activity in T cell nor is Ras function required for Akt/PKB activation in response to the TCR