Gene interactions and pathways from curated databases and text-mining

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CDK8 — NPY

Text-mined interactions from Literome

Simpson et al., Arq Bras Endocrinol Metabol 2009 (Obesity) : Firmly established pathways involve the orexigenic NPY/AgRP and the anorexigenic POMC/CART neurons in the arcuate nucleus (ARC) of the hypothalamus
Resch et al., Am J Physiol Regul Integr Comp Physiol 2011 : One hour after PACAP administration, expression of pro-opiomelanocortin mRNA was significantly increased in the arcuate nuclei (ARC) , with no changes in neuropeptide Y and agouti related polypeptide mRNA levels
Yi et al., Diabetes 2012 (Insulin Resistance) : Antagonizing the NPY1 receptors by intracerebroventricular infusion of its antagonist largely blocked the hepatic insulin resistance induced by dexamethasone in the ARC
Sahu et al., Endocrinology 1998 : In addition, in the ARC and MPOA, the other hypothalamic sites associated with induction of LH surge, NPY levels increased before and during the LH surge in young rats, no change in NPY levels in these nuclei was observed in association with the attenuated LH surge in MA rats