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AKT1 — CDK4

Text-mined interactions from Literome

Yin et al., Prostate 2009 (Prostatic Neoplasms) : In prostate cancer C/EBPalpha promotes cell growth by the loss of interactions with CDK2, CDK4 , and E2F and by activation of AKT
Bai et al., Cancer Sci 2010 (Urinary Bladder Neoplasms) : Treatment with resveratrol led to G ( 1 ) phase cell cycle arrest in T24 cells by activation of p21 and downregulation of cyclin D1, cyclin dependent kinase 4 , and phosphorylated Rb. Resveratrol also inhibited the phosphorylation of Akt , whereas the phosphorylation of p38 MAPK was enhanced
Shimura et al., Oncogene 2010 (Neoplasms) : Inhibition of the AKT/GSK3beta/cyclin D1/Cdk4 pathway by the AKT inhibitor, Cdk4 inhibitor or cyclin D1 targeting small interfering RNA ( siRNA ) suppressed the radioresistance