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AKT1 — CDH2

Text-mined interactions from Literome

Rieger-Christ et al., Oncogene 2004 (Carcinoma...) : Also, while MAPK and p38 kinase inhibitors did not alter the invasive behavior of these cells, an increase in the phosphorylation of Akt at serine-473 was detected in N-cadherin transfectants, suggestive of N-cadherin mediated Akt activation in bladder cell invasion
Zhou et al., Mol Cancer Ther 2009 (Lung Neoplasms...) : Luteolin inhibits mdm2 through AKT and overexpression of active AKT attenuated luteolin induced expression of E-cadherin , suggesting that luteolin regulates E-cadherin through AKT/mdm2 pathway
Kim et al., Neuroscience 2010 : Importantly, a neutralizing N-cadherin antibody inhibited BMP4 induced neurosphere attachment, astrocytic differentiation, and migration of neurosphere NSCs. Together, these findings show that BMP4 induced attachment of neurospheres is related to the astrocytic differentiation of these cells and that these effects are attributable, at least in part, to PI3 kinase-Akt pathway dependent induction of N-cadherin
Ciołczyk-Wierzbicka et al., Curr Med Chem 2012 (Melanoma) : In this study we investigated the role of N-cadherin in proliferation and AKT , ERK, beta-catenin signalling pathway in human melanoma cells : WM793 ( VGP ), WM115 ( VGP ) from the primary tumor site, as well as Lu1205 ( lung ) and WM266-4 ( skin ) from metastatic sites
Lelièvre et al., PloS one 2012 : The PI3-kinase/Akt survival pathway and its downstream effector Bad are not involved, as no phosphorylation of Akt or Bad proteins in response to N-cadherin engagement was observed
Cheng et al., J Clin Endocrinol Metab 2012 : Moreover, the inhibition of EGF induced ERK1/2, p38, and Akt activation by pharmacological inhibitors attenuated EGF induced Slug expression and the down-regulation of E-cadherin , as well as subsequent cell invasion
Kisslov et al., Biochim Biophys Acta 2012 (Colonic Neoplasms) : AS or Ly294002, but not H-89, decreased PKB/Akt activation as well as the nuclear localization of ß-catenin and cyclin D1 and increased the plasma membrane localization of ß-catenin with E-cadherin , suggesting that these processes are regulated by the PKB pathway ... AS or Ly294002, but not H-89, decreased PKB/Akt activation as well as the nuclear localization of ß-catenin and cyclin D1 and increased the plasma membrane localization of ß-catenin with E-cadherin , suggesting that these processes are regulated by the PKB pathway
Zhang et al., Neural development 2013 : AKT activation by N-cadherin regulates beta-catenin signaling and neuronal differentiation during cortical development ... We also find that N-cadherin regulates ß-catenin via AKT, as reduction of N-cadherin causes decreased AKT activation and reduced phosphorylation of AKT targets GSK3ß and ß-catenin