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CDH1 — IGF2
Pathways - manually collected, often from reviews:
Text-mined interactions from Literome
Morali et al., Oncogene 2001
:
We can show that ( 1 ) IGF-II induces a rapid epithelium to mesenchymal transition ; ( 2 ) IGF1R, the receptor for IGF-II, belongs to the same membrane complex as E-cadherin and beta-catenin ; ( 3 )
IGF-II induces a redistribution of beta-catenin from the plasma membrane to the nucleus and an intracellular sequestration and degradation of
E-cadherin ; ( 4 ) IGF-II induces the transcription of beta-catenin/TCF-3 target genes ... We can show that ( 1 ) IGF-II induces a rapid epithelium to mesenchymal transition ; ( 2 ) IGF1R, the receptor for IGF-II, belongs to the same membrane complex as E-cadherin and beta-catenin ; ( 3 )
IGF-II induces a redistribution of beta-catenin from the plasma membrane to the nucleus and an intracellular sequestration and degradation of
E-cadherin ; ( 4 ) IGF-II induces the transcription of beta-catenin/TCF-3 target genes
Pennisi et al., Cancer Res 2002
(Breast Neoplasms...) :
Our findings strongly suggest that the
IGF-IR plays a role in the stabilization of the
E-cadherin-catenin complex, thereby providing one possible explanation for the association between low levels of IGF-IR and a higher risk of mammary tumor metastasis ... Our findings strongly suggest that the
IGF-IR plays a role in the stabilization of the
E-cadherin-catenin complex, thereby providing one possible explanation for the association between low levels of IGF-IR and a higher risk of mammary tumor metastasis
Kim et al., BMB Rep 2009
(Carcinoma, Hepatocellular...) :
In addition, the down-regulation of snail and type 1
insulin-like growth factor receptor ( IGF-1R ) in HDAC inhibitor treated cells
induced the upregulation of thrombospondin-1 (TSP-1),
E-cadherin and claudin-3