Gene interactions and pathways from curated databases and text-mining

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CDH1 — HIF1A

Pathways - manually collected, often from reviews:

  • OpenBEL Selventa BEL large corpus: CDH1 → HIF1A (decreases)
    Evidence: HIF has recently been described as a critical factor for the regulation of E-cadherin expression in ovarian carcinoma and VHL-deficient renal cells.76,77 It has been proposed that HIF mediates repression of E-cadherin expression through the upregulation of E-cadherin-specific repressors, including Snail and SIP1.78

Text-mined interactions from Literome

Luo et al., BJU Int 2006 (Neoplasm Invasiveness...) : The expression of E-cadherin , vimentin, cathepsin D, MMP-2 and uPAR, which are proteins with established roles in the pathophysiology of invasion, could be regulated by HIF-1alpha in human prostate cancer cells ... The expression of E-cadherin , vimentin, cathepsin D, MMP-2 and uPAR, which are proteins with established roles in the pathophysiology of invasion, could be regulated by HIF-1alpha in human prostate cancer cells
Cheng et al., Cancer Lett 2013 (Ovarian Neoplasms) : Hypoxia-inducible factor 1 alpha mediates epidermal growth factor induced down-regulation of E-cadherin expression and cell invasion in human ovarian cancer cells