Gene interactions and pathways from curated databases and text-mining

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CASP7 — CDH1

Text-mined interactions from Literome

Jamal et al., J Clin Invest 2002 (Melanoma) : Downregulation of E-cadherin by ET-1/ET ( B ) involves the downstream activation of caspase-8 but not of distal, executioner caspases, and does not lead to apoptosis
Keller et al., Biochem Biophys Res Commun 2003 (Breast Neoplasms) : Cleavage of E-cadherin and deposition of the C-terminal fragment into the cytoplasm are inhibited by the caspase inhibitor DEVD-CHO
Hung et al., Exp Dermatol 2006 : Cleavage of beta- and gamma-catenin was fully abolished by caspase-3 and caspase-8 inhibitors, whereas cleavage of E-cadherin was inhibited by neither caspase nor metalloproteinase inhibitors
Sone et al., Genes Cells 2008 : Although MDCK cells transfected with GFP fused wild-type hScrib showed loss of E-cadherin expression and shrinkage of cytoplasm by UV irradiation, cells transfected with hScrib with Ala substitution of Asp-504 showed resistance to caspase dependent cleavage of hScrib and intact expression of E-cadherin
Obara et al., J Vet Med Sci 2010 (Mycoplasma Infections...) : Nitric oxide causes anoikis through attenuation of E-cadherin and activation of caspase-3 in human gastric carcinoma AZ-521 cells infected with Mycoplasma hyorhinis ... Our results indicate that NO causes anoikis throughout attenuation of E-cadherin and activation of caspase-3 in human gastric carcinoma cell line AZ-521 cells infected with M. hyorhinis