Gene interactions and pathways from curated databases and text-mining

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CASP7 — CDC6

Text-mined interactions from Literome

Bellosillo et al., Blood 2001 (Lymphoproliferative Disorders) : In addition, no cells with a hypodiploid DNA content were detected and R-CDC was not prevented by a broad-spectrum caspase inhibitor, suggesting a caspase independent mechanism
Yim et al., Mol Biol Cell 2003 : Thus, the caspase mediated cleavage of Cdc6 creates a truncated Cdc6 fragment that is retained in the nucleus and induces apoptosis
Li et al., Anticancer Drugs 2006 : In conclusion, our study reveals that NCTD can inhibit DNA replication, and induce apoptosis and caspase-3 dependent cleavage of Cdc6
Yim et al., J Cell Biol 2006 : Cdc6-UM expression attenuates the TNF-alpha induced activation of ATM and caspase-3 activities
Xiong et al., Mutat Res 2009 (Carcinoma, Hepatocellular...) : Interestingly, the G1321A polymorphism did not affect caspase mediated cleavage of Cdc6 during etoposide induced apoptosis, but it was predicted to alter the secondary structure of Cdc6 mRNA