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AKT1 — CDC37

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: AKT1 — CDC37 (physical association, affinity chromatography technology) Basso et al., J Biol Chem 2002*
• IRef Intact Interaction: Complex of AKT1-HSP90AA1-CDC37 (association, coimmunoprecipitation) Basso et al., J Biol Chem 2002*
• IRef Intact Interaction: AKT1 — CDC37 (physical association, coimmunoprecipitation) Basso et al., J Biol Chem 2002*

Text-mined interactions from Literome

Harris et al., Circ Res 2006 : The cell division cycle 37 homolog (Cdc37) is a key heat shock protein 90 (Hsp90) cochaperone for protein kinase clients, and Akt/Hsp90 interaction is dependent on Cdc37
Gray et al., Cancer Res 2007 (Prostatic Neoplasms) : We show that the loss of Cdc37 leads to reduced activity of the Erk, Akt , mTOR, and androgen induced pathways
Smith et al., Oncogene 2009 (Adenocarcinoma...) : Here, we show that silencing of CDC37 in human colon cancer cells diminished the association of kinase clients with HSP90 and reduced levels of the clients ERBB2, CRAF, CDK4 and CDK6, as well as phosphorylated AKT