◀ Back to IL12A
CD8B — IL12A
Pathways - manually collected, often from reviews:
Text-mined interactions from Literome
Grohmann et al., J Immunol 2001
:
By virtue of their respective actions on CD8 ( - ) and CD8 ( + ) DC,
IL-12 and IFN-gamma have functionally opposing effects on peptide presentation by the CD8 ( - ) DC subset, and IFN-gamma activated
CD8 ( + ) DC
mediate tolerogenic effects that prevail over the adjuvant activity of IL-12 on CD8 ( - ) DC
Iwasaki et al., Eur J Immunol 2001
(Calcium Signaling) :
A critical role for
IL-12 in CCR5 induction on T cell receptor
triggered mouse CD4 ( + ) and
CD8 ( + ) T cells
Soumelis et al., Springer Semin Immunopathol 2004
(Hypersensitivity...) :
TSLP activated human DCs produce Th2 attracting chemokines but no
IL-12 , and
induce naive CD4 ( + ) and
CD8 ( + ) T cell differentiation into effector cells with a typical pro-allergic phenotype
Wüthrich et al., J Immunol 2005
(Blastomycosis...) :
CD4 ( + ) T cells absolutely required IL-12 to control a live genetically engineered attenuated strain of Blastomyces dermatitidis given s.c. as a vaccine, whereas
CD8 ( + ) T cells were significantly less
dependent on
IL-12
Kupfahl et al., Int Immunopharmacol 2006
(Listeriosis) :
In summary these results show that lentinan enhances the protective CD8 T-cell response against L. monocytogenes probably by a mechanism that involves the
IL-12 mediated augmentation of the specific antilisterial
CD8 T-cell response
Kosaka et al., Cancer Sci 2006
:
Moreover, ASGM1 ( + )
CD8 ( + ) T cells, but not ASGM1 ( - ) CD8 ( + ) T cells, produced high levels of interferon (IFN)-gamma in
response to
IL-12 plus IL-2
Henry et al., J Immunol 2008
:
Therefore, we sought to determine the individual
roles of
IL-12 and IL-23 in naive
CD8 ( + ) T cell activation by addressing their ability to influence IFN-gamma production and cellular interaction dynamics during priming by Listeria monocytogenes infected dendritic cells ( DC )
Gozalbo et al., Frontiers in bioscience (Landmark edition) 2009
(Candidiasis) :
IFN-gamma is produced by CD4 Th1,
CD8 , gamma delta T, and natural killer ( NK ) cells, essentially in
response to both
IL-12 and/or IL-18, and plays an important role in the regulation of the immune system as well as in the control of the infectious process
Kaden et al., J Immunol 2009
:
Intriguingly, upon triggering mDCAR1,
CD8 ( + ) DCs
increased the secretion of bioactive
IL-12 , whereas IL-10 release is markedly reduced, thereby indicating that Ag recognized by mDCAR1 induces enhanced proinflammatory responses
Díaz-Montero et al., American journal of cancer research 2011
:
Here we report a simplified combinatorial approach that involves short activation of
CD8 ( + ) T cells in the
presence of
IL-12 followed by adoptive transfer into tumor bearing animals after a single injection of cyclophosphamide
Sanchez et al., Vaccine 2012
:
We have established a vaccine model system in which the primary
CD8 ( + ) T cell response is
independent of either
IL-12 or type I IFN receptors, but dependent on CD27/CD70 interactions
Dong et al., J Immunol 2012
:
CD27 stimulation promotes the frequency of IL-7 receptor expressing memory precursors and prevents
IL-12 mediated loss of
CD8 ( + ) T cell memory in the absence of CD4 ( + ) T cell help
You et al., Immunobiology 2013
:
In the MLR, DCs from older subjects induced significantly restricted proliferation of young T cells,
activation of
CD8 ( + ) T cells and expression of
IL-12 and IFN-? in T cells compared with young DCs
Flynn et al., J Exp Med 1998
:
Furthermore, T cell stimulation through OX40 inhibits IFN-gamma expression in both
CD8 T cells and
IL-12 stimulated CD4 T cells