Gene interactions and pathways from curated databases and text-mining

◀ Back to IL12A

CD8A — IL12A

Pathways - manually collected, often from reviews:

Text-mined interactions from Literome

Grohmann et al., J Immunol 1999 (Hypersensitivity, Delayed) : IL-12 acts selectively on CD8 alpha- dendritic cells to enhance presentation of a tumor peptide in vivo
Lamousé-Smith et al., J Immunol 1999 : In this study, we have investigated in detail the cytokine requirements for the generation of allospecific CD8+ CTL in vitro and have found that IL-4 can augment the generation of anti-CD8-sensitive but not anti-CD8-resistant CTL, whereas IL-2 or IL-12 can augment the generation of both anti-CD8-sensitive and anti-CD8-resistant CTL
Gherardi et al., J Virol 2000 : Moreover, at certain viral doses, coadministration of the NO inhibitor during the booster resulted in IL-12 mediated enhancement of the specific CD8 ( + ) T-cell response
Lin et al., Pediatr Allergy Immunol 2001 : Combining IL-12 and IL-15, however, resulted in decreased CB CD3+ CD8+ expression compared with IL-15 alone
Gorbachev et al., J Immunol 2001 (Dermatitis, Contact) : In the current report we tested the role of IL-12 on CD8 ( + ) T cell development during sensitization and elicitation of CHS to dinitrofluorobenzene
Grohmann et al., J Immunol 2001 : By virtue of their respective actions on CD8 ( - ) and CD8 ( + ) DC, IL-12 and IFN-gamma have functionally opposing effects on peptide presentation by the CD8 ( - ) DC subset, and IFN-gamma activated CD8 ( + ) DC mediate tolerogenic effects that prevail over the adjuvant activity of IL-12 on CD8 ( - ) DC
Iwasaki et al., Eur J Immunol 2001 (Calcium Signaling) : A critical role for IL-12 in CCR5 induction on T cell receptor triggered mouse CD4 ( + ) and CD8 ( + ) T cells
Mocikat et al., Immunity 2003 (Carcinoma...) : The activated NK cells then prime DC to produce IL-12 and to induce highly protective CD8 T cell memory responses
Soumelis et al., Springer Semin Immunopathol 2004 (Hypersensitivity...) : TSLP activated human DCs produce Th2 attracting chemokines but no IL-12 , and induce naive CD4 ( + ) and CD8 ( + ) T cell differentiation into effector cells with a typical pro-allergic phenotype
Gruber et al., Cancer Gene Ther 2005 (Philadelphia Chromosome...) : We found that IL-12 was able to eliminate pre established leukemia, and that this protection was mediated by CD4, CD8 , and NK cells in combination
Boyer et al., J Med Primatol 2005 (Monkey Diseases...) : The adjuvanted DNA vaccines illustrate that IL-12 enhances a CD8 vaccine immune response, however, different cellular profiles
Wüthrich et al., J Immunol 2005 (Blastomycosis...) : CD4 ( + ) T cells absolutely required IL-12 to control a live genetically engineered attenuated strain of Blastomyces dermatitidis given s.c. as a vaccine, whereas CD8 ( + ) T cells were significantly less dependent on IL-12
Kupfahl et al., Int Immunopharmacol 2006 (Listeriosis) : In summary these results show that lentinan enhances the protective CD8 T-cell response against L. monocytogenes probably by a mechanism that involves the IL-12 mediated augmentation of the specific antilisterial CD8 T-cell response
Blachère et al., J Immunol 2006 : Concerning the interaction between CD4 ( + ) T cells and DCs, we tested the hypothesis that CD40 engagement on DCs is critical for IL-12p70 ( IL-12 ) production and subsequent stimulation of IFN-gamma release by CD8 ( + ) T cells
Kosaka et al., Cancer Sci 2006 : Moreover, ASGM1 ( + ) CD8 ( + ) T cells, but not ASGM1 ( - ) CD8 ( + ) T cells, produced high levels of interferon (IFN)-gamma in response to IL-12 plus IL-2
Kilinc et al., J Immunol 2006 (Adenocarcinoma, Bronchiolo-Alveolar...) : Both CD8+ T cell activation and T suppressor cell purge were mediated primarily by IL-12 and required IFN-gamma
Wells et al., J Allergy Clin Immunol 2007 (Inflammation...) : Adoptive transfer of transgenic antigen-specific CD8 , but not CD4, cells resulted in increased IL-12 levels and reduced IL-13 and IL-5 levels in bronchoalveolar lavage fluid, coupled with substantially reduced airway eosinophilia after repeated allergen inhalation, a process mimicked by intranasal administration of IL-12 and inhibited by anti-IL-12 antibody
Yang et al., Blood 2007 : Together, we provide a novel mechanism for T-bet regulation, and suggest that IL-12/Stat4/T-bet play an important role in CD8 effector responses
Henry et al., J Immunol 2008 : IL-12 produced by dendritic cells augments CD8+ T cell activation through the production of the chemokines CCL1 and CCL17 ... Therefore, we sought to determine the individual roles of IL-12 and IL-23 in naive CD8 ( + ) T cell activation by addressing their ability to influence IFN-gamma production and cellular interaction dynamics during priming by Listeria monocytogenes infected dendritic cells ( DC )
Balkow et al., Exp Dermatol 2009 : When compared with untreated DC or DC treated with anti-CD40 alone, DC matured with anti-CD40 plus IL-12 and IL-18 expressed significantly more IFN-gamma and IL-12 , induced enhanced CD8 ( + ) T-cell proliferation, prolonged synaptic interaction with T cells and increased CD8 ( + ) T-cell mediated cytotoxicity
Gozalbo et al., Frontiers in bioscience (Landmark edition) 2009 (Candidiasis) : IFN-gamma is produced by CD4 Th1, CD8 , gamma delta T, and natural killer ( NK ) cells, essentially in response to both IL-12 and/or IL-18, and plays an important role in the regulation of the immune system as well as in the control of the infectious process
Kaden et al., J Immunol 2009 : Intriguingly, upon triggering mDCAR1, CD8 ( + ) DCs increased the secretion of bioactive IL-12 , whereas IL-10 release is markedly reduced, thereby indicating that Ag recognized by mDCAR1 induces enhanced proinflammatory responses
Yin et al., Vaccine 2010 (Simian Acquired Immunodeficiency Syndrome) : We further demonstrated that interleukin (IL)-12 could significantly enhance the vaccine specific CD8 lymphocyte response
Díaz-Montero et al., American journal of cancer research 2011 : Here we report a simplified combinatorial approach that involves short activation of CD8 ( + ) T cells in the presence of IL-12 followed by adoptive transfer into tumor bearing animals after a single injection of cyclophosphamide
Tamburini et al., J Immunother 2012 : IL-6 inducing whole yeast based immunotherapy directly controls IL-12 dependent CD8 T-cell responses
Sanchez et al., Vaccine 2012 : We have established a vaccine model system in which the primary CD8 ( + ) T cell response is independent of either IL-12 or type I IFN receptors, but dependent on CD27/CD70 interactions
Dong et al., J Immunol 2012 : CD27 stimulation promotes the frequency of IL-7 receptor expressing memory precursors and prevents IL-12 mediated loss of CD8 ( + ) T cell memory in the absence of CD4 ( + ) T cell help
You et al., Immunobiology 2013 : In the MLR, DCs from older subjects induced significantly restricted proliferation of young T cells, activation of CD8 ( + ) T cells and expression of IL-12 and IFN-? in T cells compared with young DCs
Stark et al., Eur J Immunol 2013 : The induction of CD40L in CD8 ( + ) T cells regulated by IL-12 and TCR signaling may enable CD8 ( + ) T cells to respond autonomously of CD4 ( + ) T cells
Maruo et al., J Immunol 1997 : IL-12 production was dependent on the presence of CD4+, but not of CD8+ , T cells, and inhibited by addition of anti-CD40 ligand (CD40L) mAb
Flynn et al., J Exp Med 1998 : Furthermore, T cell stimulation through OX40 inhibits IFN-gamma expression in both CD8 T cells and IL-12 stimulated CD4 T cells