Gene interactions and pathways from curated databases and text-mining

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CD69 — IL5

Text-mined interactions from Literome

Lin et al., Biol Neonate 2000 : The effect of interleukin-12 and interleukin-15 on CD69 expression of T-lymphocytes and natural killer cells from umbilical cord blood
Urasaki et al., J Leukoc Biol 2001 : Pivotal role of 5-lipoxygenase in the activation of human eosinophils : platelet activating factor and interleukin-5 induce CD69 on eosinophils through the 5-lipoxygenase pathway ... It has been reported that interleukin (IL)-5 , but not platelet activating factor (PAF), can induce CD69 on human eosinophils in vitro ... Because HES eosinophils contain abundant cytosolic phospholipase A2 (cPLA2) and 5-lipoxygenase (5-LO), we examined the roles of several enzymes involved in the metabolism of arachidonic acid in the PAF- or IL-5 induced CD69 expression on eosinophils ... The CD69 expression induced by PAF and IL-5 on HES eosinophils and that by IL-5 on normal eosinophils were both inhibited by AA861 and MK-886, inhibitors of 5-LO activity ... In addition, AACOCF3, a selective cPLA2 inhibitor, inhibited IL-5 induced CD69 expression on normal eosinophils, although it hardly affected either IL-5- or PAF induced CD69 expression on HES eosinophils
Dallaire et al., Clin Exp Allergy 2002 (Asthma) : Migration through Matrigel did not modify CD69 expression compared with the one obtained in the presence of IL-5 alone ; however, incubation of eosinophils on Matrigel decreased IL-5 induced CD69 ( P = 0.0001 )
Tchórzewski et al., Med Sci Monit 2005 (Autoimmune Diseases...) : We analyzed reactive oxygen intermediate ( ROI ) production by peripheral blood granulocytes, the production of IL-2, IL-5 , IL-10, IL-12, and TNF-alpha cytokines by lymphocytes, and the activation of CD25, CD26, CD69 , CD71, and HLA DR antigen expression
Matsuwaki et al., Pharmacology 2005 : The synthetic PPARgamma agonist troglitazone inhibits IL-5 induced CD69 upregulation and eosinophil derived neurotoxin release from eosinophils ... We investigated the effect of a PPARgamma agonist on human eosinophil functions such as IL-5 induced CD69 surface expression and EDN release ... IL-5 significantly induced eosinophil CD69 surface expression analyzed using flow cytometry and EDN release measured by ELISA ... IL-5 induced eosinophil CD69 surface expression and EDN release were significantly inhibited by the synthetic PPARgamma agonist troglitazone, and these effects were reversed by a PPARgamma antagonist
Zhao et al., Leukemia 2008 (Hypersensitivity, Delayed) : sorafenib also caused G ( 0 ) /G ( 1 ) phase arrest, inhibition of CD25 and CD69 expression, interleukin-2 production and LCK phosphorylation in the T cells ; all of these effects exhibited dose and time dependence
Ito et al., Int Arch Allergy Immunol 2008 : Treatment with HGF suppressed interleukin-5 induced upregulation of CD69 expression, ROS production and EDN release from human eosinophils
Lampinen et al., J Leukoc Biol 2008 (Colitis, Ulcerative...) : Culture of blood eosinophils with IL-5 and IL-13 caused increased CD44 expression, whereas IL-5 and IFN-gamma induced elevated CD69 expression
Hartnell et al., Immunology 1993 (Asthma) : CD69 expression was also induced by interleukin-3 (IL-3), IL-5 and interferon-gamma (IFN-gamma), but stimulation of eosinophils with platelet activating factor (PAF) ( 10 ( -6 ) M ) for up to 2 hr did not induce CD69 expression
Morii et al., Nihon rinsho. Japanese journal of clinical medicine 1993 (Inflammation...) : Further, in vitro stimulation of PB eosinophils by IL-3, IL-5 , GM-CSF and PMA induced CD69 expression on PB eosinophils
Wedi et al., J Allergy Clin Immunol 1997 (Asthma...) : In contrast, IL-3, IL-5 , and granulocyte-macrophage-colony stimulating factor caused an upregulated expression of CD69