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CD69 — IL5
Text-mined interactions from Literome
Lin et al., Biol Neonate 2000
:
The
effect of
interleukin-12 and interleukin-15 on
CD69 expression of T-lymphocytes and natural killer cells from umbilical cord blood
Urasaki et al., J Leukoc Biol 2001
:
Pivotal role of 5-lipoxygenase in the activation of human eosinophils : platelet activating factor and
interleukin-5 induce
CD69 on eosinophils through the 5-lipoxygenase pathway ... It has been reported that
interleukin (IL)-5 , but not platelet activating factor (PAF), can
induce CD69 on human eosinophils in vitro ... Because HES eosinophils contain abundant cytosolic phospholipase A2 (cPLA2) and 5-lipoxygenase (5-LO), we examined the roles of several enzymes involved in the metabolism of arachidonic acid in the PAF- or
IL-5 induced
CD69 expression on eosinophils ... The
CD69 expression
induced by PAF and
IL-5 on HES eosinophils and that by IL-5 on normal eosinophils were both inhibited by AA861 and MK-886, inhibitors of 5-LO activity ... In addition, AACOCF3, a selective cPLA2 inhibitor, inhibited
IL-5 induced
CD69 expression on normal eosinophils, although it hardly affected either IL-5- or PAF induced CD69 expression on HES eosinophils
Dallaire et al., Clin Exp Allergy 2002
(Asthma) :
Migration through Matrigel did not modify CD69 expression compared with the one obtained in the presence of IL-5 alone ; however, incubation of eosinophils on Matrigel decreased
IL-5 induced
CD69 ( P = 0.0001 )
Tchórzewski et al., Med Sci Monit 2005
(Autoimmune Diseases...) :
We analyzed reactive oxygen intermediate ( ROI ) production by peripheral blood granulocytes, the production of IL-2,
IL-5 , IL-10, IL-12, and TNF-alpha cytokines by lymphocytes, and the
activation of CD25, CD26,
CD69 , CD71, and HLA DR antigen expression
Matsuwaki et al., Pharmacology 2005
:
The synthetic PPARgamma agonist troglitazone inhibits
IL-5 induced
CD69 upregulation and eosinophil derived neurotoxin release from eosinophils ... We investigated the effect of a PPARgamma agonist on human eosinophil functions such as
IL-5 induced
CD69 surface expression and EDN release ...
IL-5 significantly
induced eosinophil
CD69 surface expression analyzed using flow cytometry and EDN release measured by ELISA ...
IL-5 induced eosinophil
CD69 surface expression and EDN release were significantly inhibited by the synthetic PPARgamma agonist troglitazone, and these effects were reversed by a PPARgamma antagonist
Zhao et al., Leukemia 2008
(Hypersensitivity, Delayed) :
sorafenib also caused G ( 0 ) /G ( 1 ) phase arrest,
inhibition of CD25 and
CD69 expression,
interleukin-2 production and LCK phosphorylation in the T cells ; all of these effects exhibited dose and time dependence
Ito et al., Int Arch Allergy Immunol 2008
:
Treatment with HGF suppressed
interleukin-5 induced upregulation of
CD69 expression, ROS production and EDN release from human eosinophils
Lampinen et al., J Leukoc Biol 2008
(Colitis, Ulcerative...) :
Culture of blood eosinophils with IL-5 and IL-13 caused increased CD44 expression, whereas
IL-5 and IFN-gamma
induced elevated
CD69 expression
Hartnell et al., Immunology 1993
(Asthma) :
CD69 expression was also induced by interleukin-3 (IL-3),
IL-5 and interferon-gamma (IFN-gamma), but stimulation of eosinophils with platelet activating factor (PAF) ( 10 ( -6 ) M ) for up to 2 hr did not
induce CD69 expression
Morii et al., Nihon rinsho. Japanese journal of clinical medicine 1993
(Inflammation...) :
Further, in vitro stimulation of PB eosinophils by IL-3,
IL-5 , GM-CSF and PMA
induced CD69 expression on PB eosinophils
Wedi et al., J Allergy Clin Immunol 1997
(Asthma...) :
In contrast, IL-3,
IL-5 , and granulocyte-macrophage-colony stimulating factor
caused an upregulated expression of
CD69