Gene interactions and pathways from curated databases and text-mining

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AKT1 — CD40LG

Text-mined interactions from Literome

Arron et al., J Biol Chem 2001 : A positive regulatory role for Cbl family proteins in tumor necrosis factor related activation induced cytokine ( trance ) and CD40L mediated Akt activation ... TRANCE and CD40L mediated Akt activation is defective in Cbl-b -/- dendritic cells, and CD40L mediated Akt activation is defective in c-Cbl -/- B cells
Tai et al., Cancer Res 2005 (Multiple Myeloma) : Immunoblotting analysis specifically showed that PI3-K/AKT , nuclear factor-kappaB (NF-kappaB), and extracellular signal regulated kinase activation induced by CD40L ( 5 mug/mL ) was inhibited by CHIR-12.12 ( 5 mug/mL )
Chakrabarti et al., Arterioscler Thromb Vasc Biol 2005 (Atherosclerosis...) : Soluble CD40L enhances platelet activation, aggregation, and platelet-leukocyte conjugation, as well as increases stimulation induced platelet release of RONS through activation of Akt and p38 MAP kinase signaling pathways
Georgakis et al., Br J Haematol 2006 (Hodgkin Disease) : Akt phosphorylation was further induced by CD30 ligand (CD30L), CD40L and receptor activator of nuclear factor kappa B ( RANK ) ligand
Chakrabarti et al., J Biol Chem 2007 (Inflammation) : These data support a mechanism whereby redox-sensitive CD40-CD40L interactions induce activation of Akt and p38 MAPK, leading to stimulation of NFkappaB and enhanced synthesis of CD40L and MCP1