Gene interactions and pathways from curated databases and text-mining

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CD40 — MAPK14

Pathways - manually collected, often from reviews:

Text-mined interactions from Literome

Brady et al., Biochem Biophys Res Commun 2001 (Hypersensitivity) : Under the same conditions CD40 caused activation of p38 MAPK , whereas IL-4 was ineffective
Manning et al., Eur J Immunol 2002 : Engagement of CD40 by its ligand induces IKK and mitogen activated protein kinase ( MAPK ) phosphorylation and transcriptional activation, leading to activation and differentiation of B cells
Tan et al., EMBO J 2002 : CD40 ligation results in a time dependent increase in p44/42 MAPK activation in neuronal cells
Li et al., American journal of physiology. Renal physiology 2002 : CD40 ligation stimulates MCP-1 and IL-8 production, TRAF6 recruitment, and MAPK activation in proximal tubule cells
Zhang et al., J Allergy Clin Immunol 2002 : CD40 mediated p38 mitogen activated protein kinase activation is required for immunoglobulin class switch recombination to IgE ... CD40 activation of p38 MAPK correlated with CD40 dependent IgE production, and IgE suppression by SB203580 correlated with the inhibition of CD40 activated p38 MAPK phosphorylation
Basaki et al., Arch Biochem Biophys 2002 (Burkitt Lymphoma) : We report here that CD40 induced TRAF3 dependent activation of mitogen activated protein kinase ( MAPK ) /extracellular signal regulated kinase ( ERK ) kinase 1 ( MEK1 ) is involved in the upregulation of IL-4-driven germline C epsilon transcription in a human Burkitt 's lymphoma B cell line, DG75
Awasthi et al., J Exp Med 2003 (Leishmaniasis, Cutaneous) : The inhibition of CD40 induced iNOS2 expression by SB203580, a p38-mitogen activated protein kinase ( p38MAPK ) -specific inhibitor, and the reversal of the inhibition by anisomycin, a p38MAPK activator, suggested a crucial role of p38MAPK in CD40 signaling ... Indeed, the CD40 induced p38MAPK phosphorylation, iNOS2 expression and anti-leishmanial function were impaired in Leishmania infected macrophages but were restored by anisomycin
Li et al., American journal of physiology. Renal physiology 2004 (MAP Kinase Signaling System) : Disruption of caveolae with filipin diminished CD40 mediated MAPK activation and blunted downstream monocyte chemoattractant protein-1 ( MCP-1 ) and IL-8 production ... We conclude that in human renal proximal tubule epithelial cells, CD40 and its downstream MAPK signaling proteins are located in membrane rafts and that disruption of caveolae or dislodgment of signaling proteins from the CSD diminishes MAPK activation and IL-8 and MCP-1 production in these cells
Inoue et al., J Immunol 2004 (MAP Kinase Signaling System) : IL-10 significantly inhibited CD40 induced activation of the ERK, p38 MAPK , and NF-kappaB pathways ; however, inhibition by IL-4 was limited to the ERK pathway in monocytes
Mathur et al., Nat Med 2004 (MAP Kinase Signaling System) : Leishmania skews CD40 signaling toward ERK-1/2, inducing IL-10, which inhibits activation of CD40 induced p38MAPK and expression of inducible nitric oxide synthase-2 ( iNOS-2 ) and IL-12 ... ERK-1/2 inhibition or IL-10 neutralization restores CD40 induced p38MAPK activation and parasite killing in macrophages and the BALB/c mouse, a susceptible host
Kamemura et al., Atherosclerosis 2006 (Atherosclerosis...) : Pretreatment with the MAPK kinase inhibitor, U0126, completely inhibited chylomicron remnants induced CD40 protein expression, whereas the p38 MAPK inhibitor, SB203580, had no effect
Lee et al., Arthritis Rheum 2006 (Arthritis, Rheumatoid) : CD40 ligation of RASFs also induced activation of ERK-1/2, p38 MAPK , and NF-kappaB and up-regulation of CD40 ligation induced RANKL expression, whereas osteoclastogenesis was reduced in RASFs transfected with a dominant negative mutant of IkappaB alpha or by an NF-kappaB inhibitor
Chakrabarti et al., J Biol Chem 2007 (Inflammation) : These data support a mechanism whereby redox-sensitive CD40-CD40L interactions induce activation of Akt and p38 MAPK , leading to stimulation of NFkappaB and enhanced synthesis of CD40L and MCP1
Miyazawa et al., J Toxicol Sci 2008 (MAP Kinase Signaling System) : In particular, inhibition of p38 MAPK suppressed CD86, CD54, and CD40 expression induced by DNCB and CD86 expression induced by NiSO ( 4 ) while inhibition of ERK pathways suppressed CD86, CD54 and CD40 expression induced by DNCB and NiSO ( 4 )
Mukherjee et al., J Leukoc Biol 2008 (MAP Kinase Signaling System...) : iRBCs regulate CD40 induced p38MAPK
Xia et al., Atherosclerosis 2009 (Atherosclerosis...) : Anthocyanin attenuates CD40 mediated endothelial cell activation and apoptosis by inhibiting CD40 induced MAPK activation
Ha et al., Exp Mol Med 2011 : We describe an alternative ROS production pathway that is triggered by CD40 ligation, involves 5-lipoxygenase (5-LO), and results in activation of p38 MAPK
Tsuji et al., Int Immunopharmacol 2012 : SA981 at a concentration of 30 µM attenuated CD40 mediated Akt phosphorylation, but not p38MAPK or I?Ba phosphorylation
Sarma et al., PloS one 2012 : Depending on the strength of signal dose, CD40 receptor ( CD40 ) controls ERK-1/2 and p38MAPK activation
Berberich et al., EMBO J 1996 : In summary, CD40 signaling preferentially induces SAPK but not MAPK
Salmon et al., J Immunol 1997 : Cross linking of the B cell Ag receptor (BCR) or CD40 on freshly isolated or LPS activated splenic B cells or the immature B lymphoma, WEHI 231, resulted in activation of p38 MAPK and MAPKAP kinase-2 ... We conclude that the activation of p38 MAPK and MAPKAP kinase-2 by cross linking of the TCR, BCR, Fas, or CD40 was not correlated with their roles in regulating lymphocyte survival, and that suppression of kinase activity did not inhibit the induction of apoptosis
Cao et al., J Biol Chem 1998 (Graves Disease) : CD40 cross linking enhances mitogen activated protein kinase activation, and interrupting this pathway attenuates the PGHS-2 induction