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CD40 — CHUK
Pathways - manually collected, often from reviews:
-
WikiPathways NLR Proteins:
IKBKG/CHUK/IKBKB
→
Complex of RELA-CD40
(activation)
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
-
STRING interaction:
CHUK
—
CD40
(interaction, mapped from grid)
-
STRING interaction:
CD40
—
CHUK
(interaction, mapped from grid)
Text-mined interactions from Literome
Kosaka et al., Eur J Immunol 1999
:
Activation and
regulation of the
IkappaB kinase in human B cells by
CD40 signaling
Manning et al., Eur J Immunol 2002
:
Engagement of
CD40 by its ligand
induces IKK and mitogen activated protein kinase ( MAPK ) phosphorylation and transcriptional activation, leading to activation and differentiation of B cells
Ho et al., Blood 2005
(Lymphoma, B-Cell...) :
API2-MALT1 and exogenous MALT1 increased constitutive NF-kappa B activity and enhanced
I kappa B kinase (IKK) activation
induced by
CD40 stimulation
Mukundan et al., J Immunol 2005
:
However, ligation of a CD40 mutant lacking a functional TRAF6 binding site did not initiate inflammatory cytokine production, and this mutant was found to be defective in
CD40 mediated
activation of ERK1/2, as well as
IkappaB kinase (IKK) and NF-kappaB ... Finally, treatment of monocytes with a cell-permeable peptide corresponding to the TRAF6 binding motif of CD40 inhibited
CD40 activation of ERK1/2,
IKK , and inflammatory cytokine production
Chan et al., Biochem Biophys Res Commun 2005
:
Tpl2/COT1 was shown to participate in CD40 signaling based on the ability of a catalytically inactive mutant to suppress
CD40 mediated
IkappaB kinase activation and induction of NFkappaB-responsive promoters, without affecting signaling by TNF
Taguchi et al., Genes Cells 2009
:
TRAF6 is essential for osteoclastogenesis and for both RANK- and
CD40 mediated
activation of
IKK and MAPKs