Gene interactions and pathways from curated databases and text-mining

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CASP5 — CD40

Text-mined interactions from Literome

Mackus et al., Int Immunol 2002 : CD40 ligation and TNF-alpha prevented release of cytochrome c and activation of caspase-3 , which could not be explained by effects on the expression of Bcl-2, Bcl-x ( L ) or Bax
Takahashi et al., J Immunother 2005 : Although caspase-1 inhibitor completely abolished the production of IL-18, anti-IL-18 mAb and caspase-1 inhibitor partially inhibited the increase in ICAM-1 and CD40 expression induced by doxazosin, prazosin, and terazosin
Curnock et al., Cell Immunol 1998 (Burkitt Lymphoma) : Taken together these data indicate that the CD40 of Ramos BL B cells is linked to PI3-kinase independent and -dependent routes of survival : CD40 mediated inhibition of AgR triggered caspase-3-like activity, PARP cleavage, and CD40 triggered Bcl-XL expression are PI3-kinase independent, whereas PI3-kinase is critical for CD40 mediated rescue of this cellular population from AgR triggered growth inhibition, caspase-3 processing, and apoptosis