Gene interactions and pathways from curated databases and text-mining

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AKT1 — CD40

Text-mined interactions from Literome

Davies et al., Mol Cell Biol 2005 : Interestingly, whereas the TRAF6 interacting membrane-proximal domain of CD40 has a minor role in signal transduction, studies utilizing TRAF6 knockout fibroblasts and RNA interference in epithelial cells reveal that the CD40 induced activation of NF-kappaB, JNK, p38, and Akt requires the integrity of TRAF6
Aiba et al., Immunity 2006 : Together, our findings suggest that BANK attenuates CD40 mediated Akt activation, thereby preventing hyperactive B cell responses
Benson et al., Eur J Immunol 2006 : In contrast, CD40 rescue was completely abrogated in TRAF6-deficient B cells, which showed reduced activation of Akt in response to CD40 engagement
Park et al., Nat Biotechnol 2006 (Lymphoma...) : Lipopolysaccharide or CD40 signaling stabilizes Akt1 , promoting both activation and Bcl-2 dependent survival of DCs
Chakrabarti et al., J Biol Chem 2007 (Inflammation) : These data support a mechanism whereby redox-sensitive CD40-CD40L interactions induce activation of Akt and p38 MAPK, leading to stimulation of NFkappaB and enhanced synthesis of CD40L and MCP1
Lam et al., J Biol Chem 2007 : Leptin induces CD40 expression through the activation of Akt in murine dendritic cells
Lee et al., Journal of cell communication and signaling 2007 : We found that CD40 activated JNK, p38, and Akt via redox dependent pathways that were sensitive to ROS depletion by NAC and ebselen ... The differential requirement for ROS in the activation of ERK, JNK, p38, and Akt by the BCR, CD40 , and CXCR4 likely reflects the multiplicity of upstream activators for each of these kinases, only some of which may be regulated in a redox dependent manner
Riol-Blanco et al., Nat Immunol 2009 : Direct stimulation of the IS component CD40 on DCs leads to the activation of Akt1 , suggesting the involvement of this receptor in the antiapoptotic effects observed upon IS formation
Pallier et al., Kidney Int 2010 : This phenotype was associated with the following specific characteristics which include an inhibitory signal ( decreased FcgammaRIIA/FcgammaRIIB ratio ) ; a preventive signal of hyperactive B-cell response ( an increase in BANK1, which negatively modulates CD40 mediated AKT activation ) ; an increased number of B cells expressing CD1d and CD5 ; an increased BAFF-R/BAFF ratio that could explain why these patients have more peripheral B cells ; and a specific autoantibody profile
Nadiri et al., Eur J Immunol 2011 : As to the biological outcomes of the CD40/lipid raft association, we show that disrupting lipid raft integrity selectively abolishes CD40 mediated Akt phosphorylation ... In addition, replacing the transmembrane domain of CD40 with that of CD45 ( a protein excluded from lipid rafts ) dramatically reduced CD40 mediated Akt phosphorylation and B7.1 upregulation, while not influencing p38, ERK and JNK activation
Tsuji et al., Int Immunopharmacol 2012 : Bucillamine inhibits CD40 mediated Akt activation and antibody production in mouse B-cell lymphoma ... SA981 at a concentration of 30 µM attenuated CD40 mediated Akt phosphorylation, but not p38MAPK or I?Ba phosphorylation