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AKT1 — CD38
Text-mined interactions from Literome
Zubiaur et al., J Biol Chem 2002
:
Moreover, in these cells,
anti-CD38 or anti-CD3 stimulation
leads to
protein kinase B/Akt and Erk activation, suggesting that the CD3-zeta-immunoreceptor tyrosine based activation motifs are not required for CD38 signaling in T cells ... Moreover, in these cells,
anti-CD38 or anti-CD3 stimulation
leads to protein kinase
B/Akt and Erk activation, suggesting that the CD3-zeta-immunoreceptor tyrosine based activation motifs are not required for CD38 signaling in T cells ... Consistent with this, cholesterol depletion with methyl-beta-cyclodextrin substantially reduces
CD38 mediated
Akt activation while enhancing CD38 mediated Erk activation
Lee et al., Carcinogenesis 2006
(Colorectal Neoplasms) :
We further provide the evidence that
t10 , c12-CLA
inhibited the phosphorylation of
AKT and the blockage of GSK-3 by siRNA abolished t10, c12-CLA induced ATF3 and NAG-1 expression
Choi et al., Br J Nutr 2007
(Insulin Resistance) :
The phosphorylation of insulin receptor substrate-1 on serine decreased in the livers of all three supplemented groups, while subsequent
Akt phosphorylation
increased only in the
t10 , c12-CLA-mix group
Zumaquero et al., Exp Cell Res 2010
:
Indeed,
CD38 is enzymatically active in both exosomes and MR, and CD38 ligation
induces Akt/PKB and Erk activation, which is accompanied by increased translocation of CD38 into MR. In conclusion, the present study indicates that CD38 localizes to MR, where it promotes cell signaling, and it is exported out of the cells through the exosome mediated exocytic pathway, where it may act as an intercellular messenger ... Indeed,
CD38 is enzymatically active in both exosomes and MR, and CD38 ligation
induces Akt/PKB and Erk activation, which is accompanied by increased translocation of CD38 into MR. In conclusion, the present study indicates that CD38 localizes to MR, where it promotes cell signaling, and it is exported out of the cells through the exosome mediated exocytic pathway, where it may act as an intercellular messenger
Jude et al., Am J Respir Cell Mol Biol 2012
(Asthma) :
CD38 expression and
activation of
Akt , NF-?B, and AP-1 were determined