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CD28 — IL12A

Text-mined interactions from Literome

Cheung et al., Mol Immunol 1999 : Thus ligation of CD28 in the presence of IL-12 results in a synergistic increase in production of the cytokine
Chang et al., J Immunol 2000 (Encephalomyelitis, Autoimmune, Experimental) : We demonstrate that IL-2 and IL-12 resulting from CD28/B7 interactions both play a critical role in the induction of expression of the IL-12Rbeta2 subunit and as a result the differentiation of pathogenic autoreactive effector cells
Kim et al., Blood 2002 : The 4-1BB was induced preferentially on the CB CD28 ( - ) CD8 ( + ) T cells when CD28 down-regulation was induced by interleukin 15 (IL-15) and IL-12 stimulation
Warrington et al., Blood 2003 : Costimulation of the T-cell and IL-12 receptors induced the transcription of CD28 in approximately 50 % of CD4 ( + ) CD28 ( null ) T-cell clones and lines ... IL-12 by itself did not restore CD28 expression
Ito et al., J Immunol 2003 (Encephalomyelitis, Autoimmune, Experimental) : MOG-specific T cells stimulated with anti-CD3 and anti-CD28 in the presence of IL-12 or IL-18 alone transferred only mild experimental autoimmune encephalomyelitis ( EAE ) into a low percentage of recipients
Ortega et al., J Leukoc Biol 2009 (Psoriasis) : These cells are refractory to Tregs but show a proliferative response to anti-CD3/CD28 stimulation that is enhanced by IL-12 and IL-15
DeKruyff et al., J Immunol 1997 : IL-12 production in this T cell dependent system increased in direct proportion to Ag concentration and required TCR ligation but not CD28 costimulation
Monteleone et al., Gut 1998 (Colitis...) : IL-12 did not induce proliferation of either unstimulated or preactivated T-LPLs and it did not enhance the CD2/CD28 stimulated T-LPL proliferative response
Ding et al., J Immunol 1998 : Enhancement of costimulation by engagement of CD28 only resulted in augmentation of the capacity of the weak agonist APL to induce proliferation and IL-2/IL-3 production, but not CD40L or IL-12Rbeta2 chain expression on T cells, CD80/CD86 expression on APC, IL-12 secretion, or IFN-gamma production