◀ Back to STAT3

CD274 — STAT3

Text-mined interactions from Literome

Marzec et al., Proc Natl Acad Sci U S A 2008 (Lymphoma, T-Cell) : STAT3 binds to the CD274 gene promoter in vitro and in vivo, as shown in the gel electromobility shift and chromatin immunoprecipitation assays, and is required for the PD-L1 gene expression, as demonstrated by siRNA mediated STAT3 depletion
Wasik et al., Semin Oncol 2009 (Cell Transformation, Neoplastic...) : Recent data indicate that NPM/ALK also promotes immune evasion of the ALK ( + ) TCL by inducing through STAT3 activation the expression of immunosuppressive cytokines interleukin-10 (IL-10) and transforming growth factor-beta ( TGFss ) and cell surface protein CD274 ( PD-L1, B7-H1 )
Matta et al., J Immunol 2012 (Hypersensitivity, Delayed) : IL-27 production and STAT3 dependent upregulation of B7-H1 mediate immune regulatory functions of liver plasmacytoid dendritic cells
Jiang et al., Clin Cancer Res 2013 (Melanoma) : BRAFi resistance leads to increased expression of PD-L1 in melanoma cells, mediated by c-Jun and STAT3