Gene interactions and pathways from curated databases and text-mining

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CD1D — IL12A

Text-mined interactions from Literome

Yue et al., Proc Natl Acad Sci U S A 2005 : This study demonstrates that CD1d ligation alone, in the absence of iNKT, could rapidly ( within 24 h ) stimulate production of bioactive IL-12p70 by CD1d+ human peripheral blood monocytes as well as iDCs ... IFNgamma alone had no effect, but it markedly enhanced CD1d stimulated IL-12 production ... CD1d ligation on the human monocytic cell line THP-1 similarly specifically stimulated IL-12 production ... Selective NF-kappaB inhibition blocked this CD1d stimulated IL-12 production ... Finally, CD1d ligation could also enhance IL-12 production in the presence of suboptimal LPS or CD40 stimulation
Kawana et al., Infect Immun 2008 : Ligation of surface expressed CD1d by monoclonal antibody cross linking promoted interleukin-12 (IL-12) and IL-15, but not IL-10, production in vaginal and penile urethral cells
Yue et al., J Immunol 2010 (Cardiovirus Infections) : CD1d ligation in vivo enhanced systemic IL-12 , IFN-gamma, and IFN-alpha and was protective against infection by encephalomyocarditis virus, suggesting an alternative interpretation for previous results involving CD1d `` blocking '' in other systems
Ma et al., J Surg Res 2013 : T cells pre sensitized by LPS stimulated imDCs showed remarkably elevated proliferation in response to T cells from either BALB/c or C57BL/6 mice ( P < 0.01 ). We observed a significant decrease in the proliferation of T cells pre sensitized by stimulated imDCs after CD1d blockade. Lipopolysaccharide stimulation caused elevated the production of IL-12 and tumor necrosis factor-a (TNF-a) ( P < 0.01 ) and decreased the secretion of IL-10 ( P < 0.05 ). The addition of CD1d neutralization antibody did not significantly change the concentrations of IL-12, TNF-a, or IL-10 produced by imDCs cultured in the presence of LPS ( P > 0.05 )