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CCR5 — IL12A
Text-mined interactions from Literome
Biasin et al., J Infect Dis 2000
:
However, interleukin (IL)-6, IL-10,
IL-12 , interferon (IFN)-gamma, and tumor necrosis factor (TNF)-alpha and -beta mRNA were elevated in PBMC and cervical mucosa biopsy specimens of ESN and HIV infected women ;
CCR5 and CXCR4 mRNA were
augmented in cervical mucosa biopsy specimens, but not in PBMC, of ESN and HIV infected women ; HIV-specific IFN-gamma secreting cells were detected in vaginal washes of ESN and HIV infected women ; and phenotypic alterations were present in PBMC of ESN women
Iwasaki et al., Eur J Immunol 2001
(Calcium Signaling) :
A critical
role for
IL-12 in
CCR5 induction on T cell receptor triggered mouse CD4 ( + ) and CD8 ( + ) T cells ... However, TCR triggered T cells expressed IL-12 receptor, and stimulation with recombinant
IL-12 resulted in high levels of
CCR5 expression on both CD4 ( + ) and CD8 ( + ) T cells ... Stimulation of these CCR5 positive T cells with the relevant chemokine MIP-1 alpha elicited Ca ( 2+ ) influx, showing that
IL-12 induced
CCR5 is functional ... These results indicate a critical
role for
IL-12 in the induction of
CCR5 on TCR triggered T cells
Mukai et al., J Leukoc Biol 2001
:
These results indicate that
IL-12 plays a critical role in
CCR5 expression on Th1 cells and consequently contributes to CCR5 mediated activation of LFA-1 molecules
Iwasaki et al., J Immunol 2001
:
A mandatory role for STAT4 in
IL-12 induction of mouse T cell
CCR5 ... In contrast, TCR triggered STAT4 ( -/- ) T cells failed to express
CCR5 in
response to
IL-12
Yang et al., J Clin Immunol 2001
:
However, when purified T cells instead of unfractionated PBL were stimulated with anti-CD3/CD28 and then exposed to IL-12 or IFN-alpha,
CCR5 expression was
induced by
IL-12 but not by IFN-alpha ... However, when purified T cells instead of unfractionated PBL were stimulated with anti-CD3/CD28 and then exposed to IL-12 or IFN-alpha,
CCR5 expression was
induced by
IL-12 but not by IFN-alpha
Aliberti et al., Mol Immunol 2002
:
Our findings indicate that the potent
IL-12 response observed is highly
dependent on both the chemokine receptor
CCR5 and G ( i ) -protein coupled signaling
Nakajima et al., Eur J Immunol 2002
:
The induction of another Th1 chemokine receptor
CCR5 absolutely
required IL-12 stimulation and STAT4 involvement
Losana et al., J Leukoc Biol 2002
(HIV Infections) :
IFN-gamma and
IL-12 differentially
regulate CC-chemokine secretion and
CCR5 expression in human T lymphocytes
Rodriguez-Galán et al., J Immunol 2005
:
In contrast,
IL-18-plus-IL-12 specifically
induced CCR5 expression
Zhu et al., J Pharmacol Exp Ther 2006
(Encephalomyelitis, Autoimmune, Experimental) :
In vitro study also showed PSE inhibited interferon (IFN)-gamma dependent CXCR3 expression in T cells through suppressing T-cell receptor ( TCR ) ligation induced IFN-gamma production, whereas it inhibited
interleukin (IL)-12 dependent
CCR5 expression through suppressing IL-12 reactivity in TCR triggered T cells
Ni et al., Br J Pharmacol 2009
(Encephalomyelitis, Autoimmune, Experimental) :
In addition, TAK-779 did not affect production of
IL-12 by antigen presenting cells,
CCR5 induction on T cells and the potential of MOG-specific T cells to transfer EAE