Geddis et al., J Biol Chem 2001
:
Expression of constitutively active Akt in BaF3/Mpl cells restored the ability of thrombopoietin to promote cell cycling in the presence of LY294002
Gude et al., Circ Res 2006
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Akt promotes increased cardiomyocyte cycling and expansion of the cardiac progenitor cell population
Catalucci et al., J Biol Chem 2009
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Akt increases sarcoplasmic reticulum Ca2+ cycling by direct phosphorylation of phospholamban at Thr17
Wen et al., Hepatology 2012
(Carcinoma, Hepatocellular...) :
Cyclin G1 overexpression enhanced Akt activation through interaction with p85 ( regulatory subunit of phosphoinositide 3-kinase [ PI3K ] ), which led to subsequent phosphorylation of glycogen synthase kinase-3ß ( GSK-3ß ) and stabilization of Snail, a critical EMT mediator