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CCND1 — CREB1
Pathways - manually collected, often from reviews:
Text-mined interactions from Literome
Lee et al., J Biol Chem 1999
(Breast Neoplasms) :
Dominant negative mutants of
CREB and ATF-2 but not c-Jun
inhibited pp60 ( v-src ) induction of
cyclin D1
Boulon et al., Mol Cell Biol 2002
(Breast Neoplasms) :
Our observation that Oct-1 potentiates
CREB dependent
cyclin D1 transcriptional activity independently of Ser 133 phosphorylation and E1A-sensitive coactivator function offers a new paradigm for the regulation of cyclin D1 induction by proliferative signals
Pradeep et al., Oncogene 2004
(Stomach Neoplasms) :
Since mature, amidated gastrin ( G-17 ) can induce cyclin D1, we determined whether G-17 mediated induction of
cyclin D1 transcription
involved Wnt signaling and
CRE binding protein ( CREB ) pathways
Kim et al., J Endocrinol 2006
:
Lastly, a transfection assay employing constitutively active or dominant negative CREB expression plasmids clearly demonstrated that
CREB was largely
involved in both basal and EX-induced
cyclin D1 promoter activities ... Taken together, EX-induced
cyclin D1 expression is largely dependent on the cAMP/PKA signaling pathway, and EX
increases the level of phosphorylated
CREB and more potently trans-activates cyclin D1 gene through binding of the CREB to the putative CRE site, implicating a potential mechanism underlying beta-cell proliferation by EX
Kumar et al., Clin Cancer Res 2007
(Adenocarcinoma...) :
Overexpression of kinase dead Akt mutant or phosphorylation-defective
CREB inhibited
cyclin D1 transcriptional activity ... The current study shows that Nexrutine mediated targeting of
Akt/CREB induced activation of
cyclin D1 prevents the progression of prostate cancer
Fox et al., J Biol Chem 2008
:
Regulation of
cyclin D1 and Wnt10b gene expression by
cAMP-responsive element binding protein during early adipogenesis involves differential promoter methylation ... Forced depletion of
CREB blocked Bt ( 2 ) cAMP stimulated
cyclin D1 expression and basal Wnt10b gene expression
Rozenberg et al., Mol Cancer Res 2009
(Papilloma...) :
In primary keratinocyte cultures,
A-CREB expression induced apoptosis of v-Ras ( Ha ) -infected cells and
suppressed the expression of cell cycle proteins cyclin B1 and
cyclin D1
Kim et al., Oncogene 2010
(Cell Transformation, Viral) :
Tax binds the
cyclin D1 promoter-proximal cyclic AMP response element ( CRE ) in the
presence of phosphorylated
CREB ( pCREB ) in vitro, and together the Tax-pCREB complex recruits the cellular co-activator p300 to the promoter through this unconventional Tax-responsive element
Yan et al., Dev Neurobiol 2013
:
Consistently, Western immunoblot analysis demonstrated that IGF-I
induced CREB ( CRE binding protein ) phosphorylation, while ablation of CREB expression with small interfering RNAs ( siRNA ) blocked IGF-I actions on
cyclin D1 mRNA expression and cell proliferation