Gene interactions and pathways from curated databases and text-mining

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CASP7 — CCND1

Text-mined interactions from Literome

Yu et al., Oncogene 2004 (Leukemia) : Adaphostin also induced cleavage and dephosphorylation of pRb on CDK2- and CDK4-specific sites, as well as the caspase dependent downregulation of cyclin D1
Kameswaran et al., Biomed Pharmacother 2009 (Laryngeal Neoplasms) : Indirubin-3-oxime induced growth inhibition was associated with induction of Cdk inhibitor p21, inhibition of cyclin D1 and activation of caspase-3
Kong et al., Cancer Lett 2010 (Neovascularization, Pathologic...) : The mechanisms involved inhibition of NF-kappaB activity and consequent inhibition of Bcl-2, cyclin D1 and VEGF, and activation of caspase-3
Park et al., Phytother Res 2010 : Cell death induced by the extract of P. linteus grown on PBR was shown to be associated with the upregulation of p21 ( CIP1/WAF1 ), the downregulation of cyclin D1 , anti-apoptotic protein, Bcl-2, the release of cytochrome c, and the activation of caspase-9, caspase-3 and caspase-8