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AKT1 — CCND1

Text-mined interactions from Literome

Gille et al., J Biol Chem 1999 : Activated PI 3-kinase induces cyclin D(1) transcription and E2F activity, at least in part mediated by the serine/threonine kinase Akt/PKB , and to a lesser extent the Rho family GTPase Rac
D'Amico et al., J Biol Chem 2000 (Breast Neoplasms) : Inhibition of the PI 3-kinase and AKT/protein kinase B, but not of the p38, ERK, or JNK signaling pathways, reduced ILK induction of cyclin D1 expression
Hutchinson et al., Mol Cell Biol 2001 (Hyperplasia...) : Furthermore, coexpression of Akt-DD with MTY315/322F resulted in phosphorylation of the FKHR forkhead transcription factor and translational upregulation of cyclin D1 levels
Yakes et al., Cancer Res 2002 (Breast Neoplasms) : Herceptin induced inhibition of phosphatidylinositol-3 kinase and Akt Is required for antibody mediated effects on p27, cyclin D1 , and antitumor action
Gupta et al., Cancer Res 2002 (Breast Neoplasms...) : Other contributing effects of morphine include activation of the survival signal PKB/Akt , inhibition of apoptosis, and promotion of cell cycle progression by increasing cyclin D1 ... Other contributing effects of morphine include activation of the survival signal PKB/Akt , inhibition of apoptosis, and promotion of cell cycle progression by increasing cyclin D1
Albanese et al., Mol Biol Cell 2003 : PI3K dependent induction of cyclin D1 was blocked by inhibitors of PI3K/Akt/IkappaB/IKKalpha or beta-catenin signaling
Lin et al., Mol Pharmacol 2003 : Pentoxifylline inhibits platelet derived growth factor stimulated cyclin D1 expression in mesangial cells by blocking Akt membrane translocation
Bai et al., J Biol Chem 2004 : Our results demonstrate that MPP ( + ) induces cell cycle arrest independently of its mitochondrial toxicity or the p53 status of the target cells, but rather through the proteasome- and phosphatidylinositol 3-Akt-glycogen synthase kinase-3beta dependent cyclin D1 degradation
Ouyang et al., Carcinogenesis 2006 (Skin Neoplasms) : Furthermore, inhibition of PI-3K/Akt by overexpression of Deltap85 or DN-Akt blocked arsenite induced IKK phosphorylation, IkappaBalpha degradation and cyclin D1 expression, indicating that IKK/NFkappaB is the downstream transducer of arsenite triggered PI-3K/Akt cascade
Yang et al., BMC cell biology 2006 : We found, however, that neither PI3K, AKT , GSK3, nor proliferative signaling activity in general is responsible for the S phase decline in cyclin D1 levels
Radeff-Huang et al., J Biol Chem 2007 (Brain Neoplasms...) : Furthermore, cyclin D expression was increased by TNF-alpha in a SphK- and Akt dependent manner
Yang et al., J Biol Chem 2007 (MAP Kinase Signaling System) : Insulin-like growth factor 1 (IGF-1) treatment or Akt activation attenuated the myostatin stimulated cyclin D1 degradation as well as the associated cell proliferation repression
Kumar et al., Clin Cancer Res 2007 (Adenocarcinoma...) : The current study shows that Nexrutine mediated targeting of Akt/CREB induced activation of cyclin D1 prevents the progression of prostate cancer
Ouyang et al., Environ Health Perspect 2008 (Cell Transformation, Neoplastic...) : Our results demonstrate that PI-3K/Akt mediated cyclin D1 expression is at least one key event implicated in the arsenite human skin carcinogenic effect
Dal Col et al., Blood 2008 (Lymphoma, Mantle-Cell) : Moreover, Akt inhibition down-regulated cyclin D1 by promoting its proteasome dependent degradation driven by GSK-3
Liu et al., Lab Invest 2009 (Disease Models, Animal...) : PTK/ZK also induced cell cycle arrest, accompanied by increasing the expression of p27 ( Kip1 ) and downregulation of cyclin D1 and cyclin E. PTK/ZK significantly inhibited vascular endothelial growth factor ( VEGF ) expression, as well as VEGF simulated cell proliferation and phosphorylation of Akt in activated HSCs
Lee et al., Stem Cells 2009 : BMP-4 induced beta-catenin activation and cyclin D1 expression were attenuated by phosphatidyl inositol 3-kinase (PI3K) siRNA and Akt inhibitor
Humtsoe et al., Oncogene 2010 (MAP Kinase Signaling System...) : The expression of cyclin D1 required both EGFR mediated ERK and AKT activation
Ghosh et al., Blood 2010 (Disease Progression...) : Moreover, MV-mediated AKT activation led to modulation of the beta-catenin pathway and increased expression of cyclin D1 and c-myc in BMSCs
Bai et al., Cancer Sci 2010 (Urinary Bladder Neoplasms) : Treatment with resveratrol led to G ( 1 ) phase cell cycle arrest in T24 cells by activation of p21 and downregulation of cyclin D1 , cyclin dependent kinase 4, and phosphorylated Rb. Resveratrol also inhibited the phosphorylation of Akt , whereas the phosphorylation of p38 MAPK was enhanced
Creamer et al., Mol Cell Biol 2010 : Elevating the levels of active Akt1 restores the expression of cyclin D1 and proliferation of Jak2-deficient mammary epithelial cells, which provides evidence that Akt1 acts downstream of Jak/Stat signaling
Andreu-Pérez et al., BMC cancer 2010 (Melanoma...) : The molecular analysis of tumor samples and in vitro experiments indicated that MTA induces cytostatic rather than pro-apoptotic effects inhibiting the phosphorylation of Akt and S6 ribosomal protein and inducing the down-regulation of cyclin D1
Liu et al., Acta Biochim Biophys Sin (Shanghai) 2010 : The Akt inhibitor 1701-1 significantly diminished the expression of phospho-Akt, phospho-ERK1/2, and cyclin D1 stimulated by apelin-13
Shimura et al., Oncogene 2010 (Neoplasms) : A positive feedback loop was responsible for the cyclin D1 overexpression in which constitutively active AKT was involved
Zhang et al., Experimental biology and medicine (Maywood, N.J.) 2010 : These findings demonstrate for the first time that PI3K/Akt dependent cyclin D1 activation plays an essential role in HDL induced EPC proliferation, migration and angiogenesis
Guo et al., Genes & cancer 2011 : Taken together, these findings suggest that activation of NF-?B by Pdcd4 knockdown through AKT contributes to the elevated expression of cyclin D1 , thus providing new insights into how loss of Pdcd4 expression promotes tumor development
Ni et al., BMC complementary and alternative medicine 2012 (Disease Models, Animal...) : Essential oil activated the caspase dependent apoptotic pathway, induced a rapid and transient activation of Akt and Erk1/2, and suppressed levels of cyclin D1 cdk4 expression in cultured pancreatic cancer cells
Li et al., PloS one 2012 : Pharmacological inhibition of JAK/STAT3, PI3K/Akt or MEK/ERK signaling by AG490, Wortmannin or U0126, respectively, reduced leptin induced cyclin D1 expression and NP cell proliferation