◀ Back to STAT3
CCL2 — STAT3
Text-mined interactions from Literome
Yubero et al., Biochim Biophys Acta 2009
(Pancreatitis) :
Pancreatic glutathione depletion, acinar overexpression of
monocyte chemoattractant protein-1 ( MCP-1 ) and cytokine induced neutrophil chemoattractant ( CINC ), and
activation of p38MAPK, NF-kappaB and
STAT3 were found in both AP models
Kok et al., Arthritis Rheum 2009
(Arthritis) :
Oncostatin M-induced
CCL2 transcription in osteoblastic cells is
mediated by multiple levels of STAT-1 and
STAT-3 signaling : an implication for the pathogenesis of arthritis ... In U2OS cells, STAT-1 and
STAT-3 were
involved in OSM stimulated
CCL2 expression, and both the phosphatidylinositol 3-kinase/Akt and MEK/ERK pathways were implicated in the activation of these STATs ... STAT-1 and
STAT-3 modulated the expression of c-Fos and directly
transactivated the
CCL2 promoter
Li et al., Mol Immunol 2010
:
Additionally, we show that plasmin induced the phosphorylation of
STAT3 is similar to that of IL-6 and IL-31, and protease activated receptor 1 does not
affect plasmin induced cytokine
MCP-1 release in human monocytes
Schröer et al., Cancer Res 2011
(Uterine Cervical Neoplasms) :
Our data provide evidence that
STAT3 does not directly induce MMP-9 but first
leads to a strong production of the
monocyte chemoattractant protein-1 ( CCL2 ) in the nanogram range
Pini et al., J Leukoc Biol 2012
(Inflammation...) :
However, the delayed resolution of neutrophil infiltration ; sustained production of CXCL1, CXCL2, and
CCL2 ; prolonged
activation of
STAT-3 ; and induction of MMP-7 in the pancreas, as well as heightened induction of serum amylase A of DIO mice, were blunted significantly in DIO IL-6 KO mice
Tsuyada et al., Cancer Res 2012
(Breast Neoplasms) :
Increased
CCL2 expression in activated fibroblasts
required STAT3 activation by diverse breast cancer secreted cytokines, and in turn, induced NOTCH1 expression and the CSC features in breast cancer cells, constituting a cancer-stroma-cancer signaling circuit
Zhou et al., Nutrition & metabolism 2012
:
We further showed that increased
MCP-1 mRNA levels were
due to increased phosphorylation of Signal Transducer and Activator of Transcription 3 ( STAT3 ) Ser727 but not
STAT3 Tyr705 phosphorylation, suggesting differential regulation of MCP-1 gene expression under basal and leptin stimulated conditions in adipose stem cells
Izumi et al., EMBO Mol Med 2013
(Neoplasm Metastasis...) :
Targeting the androgen receptor with siRNA promotes prostate cancer metastasis through enhanced macrophage recruitment via
CCL2/CCR2 induced
STAT3 activation ... Molecular mechanism dissection revealed that targeting PCa AR with siRNA promoted PCa cell migration/invasion via
CCL2 dependent
STAT3 activation and epithelial-mesenchymal transition (EMT) pathways
Mellado et al., J Immunol 1998
:
In contrast, when a CCR2B Tyr139Phe mutant is expressed in HEK293 cells, it is not phosphorylated in tyrosine and triggers neither
JAK2/STAT3 activation nor Ca2+ mobilization in
response to
MCP-1