Gene interactions and pathways from curated databases and text-mining

◀ Back to STAT3

CCL2 — STAT3

Text-mined interactions from Literome

Yubero et al., Biochim Biophys Acta 2009 (Pancreatitis) : Pancreatic glutathione depletion, acinar overexpression of monocyte chemoattractant protein-1 ( MCP-1 ) and cytokine induced neutrophil chemoattractant ( CINC ), and activation of p38MAPK, NF-kappaB and STAT3 were found in both AP models
Kok et al., Arthritis Rheum 2009 (Arthritis) : Oncostatin M-induced CCL2 transcription in osteoblastic cells is mediated by multiple levels of STAT-1 and STAT-3 signaling : an implication for the pathogenesis of arthritis ... In U2OS cells, STAT-1 and STAT-3 were involved in OSM stimulated CCL2 expression, and both the phosphatidylinositol 3-kinase/Akt and MEK/ERK pathways were implicated in the activation of these STATs ... STAT-1 and STAT-3 modulated the expression of c-Fos and directly transactivated the CCL2 promoter
Li et al., Mol Immunol 2010 : Additionally, we show that plasmin induced the phosphorylation of STAT3 is similar to that of IL-6 and IL-31, and protease activated receptor 1 does not affect plasmin induced cytokine MCP-1 release in human monocytes
Schröer et al., Cancer Res 2011 (Uterine Cervical Neoplasms) : Our data provide evidence that STAT3 does not directly induce MMP-9 but first leads to a strong production of the monocyte chemoattractant protein-1 ( CCL2 ) in the nanogram range
Pini et al., J Leukoc Biol 2012 (Inflammation...) : However, the delayed resolution of neutrophil infiltration ; sustained production of CXCL1, CXCL2, and CCL2 ; prolonged activation of STAT-3 ; and induction of MMP-7 in the pancreas, as well as heightened induction of serum amylase A of DIO mice, were blunted significantly in DIO IL-6 KO mice
Tsuyada et al., Cancer Res 2012 (Breast Neoplasms) : Increased CCL2 expression in activated fibroblasts required STAT3 activation by diverse breast cancer secreted cytokines, and in turn, induced NOTCH1 expression and the CSC features in breast cancer cells, constituting a cancer-stroma-cancer signaling circuit
Zhou et al., Nutrition & metabolism 2012 : We further showed that increased MCP-1 mRNA levels were due to increased phosphorylation of Signal Transducer and Activator of Transcription 3 ( STAT3 ) Ser727 but not STAT3 Tyr705 phosphorylation, suggesting differential regulation of MCP-1 gene expression under basal and leptin stimulated conditions in adipose stem cells
Izumi et al., EMBO Mol Med 2013 (Neoplasm Metastasis...) : Targeting the androgen receptor with siRNA promotes prostate cancer metastasis through enhanced macrophage recruitment via CCL2/CCR2 induced STAT3 activation ... Molecular mechanism dissection revealed that targeting PCa AR with siRNA promoted PCa cell migration/invasion via CCL2 dependent STAT3 activation and epithelial-mesenchymal transition (EMT) pathways
Mellado et al., J Immunol 1998 : In contrast, when a CCR2B Tyr139Phe mutant is expressed in HEK293 cells, it is not phosphorylated in tyrosine and triggers neither JAK2/STAT3 activation nor Ca2+ mobilization in response to MCP-1