Gene interactions and pathways from curated databases and text-mining

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CCL2 — PRKAR2A

Text-mined interactions from Literome

Fietta et al., Cytokine 2002 (MAP Kinase Signaling System...) : In addition, activation of PKA and the phosphoinoside 3-kinase (PI-3k)/p70 ribosomal S6 kinase cascade was required to have maximal MCP-1 but not IL-8 production
Yao et al., Med Sci Monit 2003 : The specific PKA inhibitor reduces MCP-1 gene expression and translation, as well as moderately reducing CSF-1 and PTHrP-R expression
Hirano et al., Eur J Pharmacol 2007 : The synergistic production of MCP-1 and IL-8 by PGD2 was mimicked by dibutyryl cAMP ( db-cAMP ) and was inhibited by a protein kinase A (PKA) inhibitor
Sun et al., Am J Physiol Gastrointest Liver Physiol 2007 (Pancreatitis) : Prostaglandin E2 modulates TNF-alpha induced MCP-1 synthesis in pancreatic acinar cells in a PKA dependent manner
Voss et al., Inflamm Allergy Drug Targets 2012 : While poly ( I:C ) induced IL-8 gene expression was solely inhibited by the NF-?B inhibitor III, MCP-1 gene induction was also blocked by PKA , p38 MAPK and JAK-STAT inhibitors