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CCL2 — CXCR4

Pathways - manually collected, often from reviews:

• KEGG Chemokine signaling pathway: CCL1/CCL11/CCL13/CCL14/CCL15/CCL16/CCL17/CCL18/CCL19/CCL2/CCL20/CCL21/CCL22/CCL23/CCL24/CCL25/CCL26/CCL27/CCL28/CCL3/CCL3L1/CCL3L3/CCL4/CCL4L1/CCL4L2/CCL5/CCL7/CCL8/CX3CL1/CXCL1/CXCL10/CXCL11/CXCL12/CXCL13/CXCL14/CXCL16/CXCL2/CXCL3/CXCL5/CXCL6/CXCL9/IL8/PF4/PF4V1/PPBP/XCL1/XCL2 → CCR1/CCR10/CCR2/CCR3/CCR4/CCR5/CCR6/CCR7/CCR8/CCR9/CX3CR1/CXCR1/CXCR2/CXCR3/CXCR4/CXCR5/CXCR6/XCR1 (protein-protein, activation)
  

Text-mined interactions from Literome

Hicks et al., Am J Pathol 2002 (Lentivirus Infections) : Neuropathogenesis of lentiviral infection in macaques : roles of CXCR4 and CCR5 viruses and interleukin-4 in enhancing monocyte chemoattractant protein-1 production in macrophages
Melchionna et al., FASEB J 2005 (Atherosclerosis) : Further, the known LSS induced inhibition of MCP-1 expression was impaired in CXCR4 overexpressing ECs
Campbell et al., J Biol Chem 2008 (HIV Infections) : We show that CCL2 up-regulates CXCR4 on resting CD4 ( + ) T cells in a CCR2 dependent mechanism, and that this augmentation of CXCR4 expression by CCL2 increases the ability of these cells to be chemoattracted to CXCR4 using gp120 and renders them more permissive to X4-tropic HIV-1 infection
Lee et al., J Virol 1998 : The MCP-1 induced calcium mobilization mediated by CCR2b signaling was unaffected by the polymorphism, but MCP-1 signaling mediated by either CCR2b- or CCR2-V64I encoded receptors resulted in heterologous desensitization ( i.e., limiting the signal response of other receptors ) of both CCR5 and CXCR4