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CCK — IGF2

Text-mined interactions from Literome

Mossner et al., Diabetes Res Clin Pract 1986 (Diabetes Mellitus, Experimental) : These studies indicate, therefore, that 125I-IGF II is internalized by pancreatic acini, and that this internalization is regulated by CCK 8
Mössner et al., J Biol Chem 1984 (Diabetes Mellitus) : Several lines of evidence suggest that this effect of CCK8 was via the CCK receptor and was mediated via a change in intracellular Ca2+ : the effect of CCK8 on inhibiting IGF II binding was blocked by the cholecystokinin antagonist N2,O2'-dibutyryl cGMP ; the cholinergic agent carbachol ( 1-100 microM ), which acts through the muscarinic receptor to increase intracellular Ca2+, also inhibited IGF II binding ; the Ca2+ ionophore A23187 ( 1-5 microM ) mimicked the effects of CCK8 and carbachol
Potau et al., Biochem Biophys Res Commun 1984 : Cholecystokinin and insulin regulate insulin-like growth factor II binding to pancreatic receptors ; evidence of a role for intracellular calcium ... Two lines of evidence suggest that this effect of cholecystokinin on basal and insulin stimulated 125I-IGF II binding was mediated via a change in intracellular calcium : ( 1 ) the cholinergic agent carbachol inhibited IGF II binding to its receptors ; ( 2 ) addition of the Ca2+ ionophore A23187 mimicked the effects of CCK8 and carbachol