Gene interactions and pathways from curated databases and text-mining

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CBL — MAPK6

Text-mined interactions from Literome

Rao et al., Proc Natl Acad Sci U S A 2002 : Finally, analysis of a ZAP-70-deficient T cell line revealed that Cbl inhibited Lck dependent mitogen activated protein kinase activation, and an intact Cbl RING finger domain was required for this functional effect
Yan et al., J Cancer Res Clin Oncol 2012 (Breast Neoplasms...) : Moreover, down-regulation of Cbl-b by shRNA led to stronger activation of ERK, JNK and p38 MAPK , more up-regulation of DR4 and DR5, and a stronger synergistic effect of bufalin and TRAIL
Gómez-Martín et al., Arthritis Rheum 2013 (Lupus Erythematosus, Systemic) : In T cells from lupus patients, Cbl-b overexpression led to increased expression of phosphorylated MAPK , thus indicating the reversibility of anergy resistance