Gene interactions and pathways from curated databases and text-mining

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CAV3 — NOS1

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

Text-mined interactions from Literome

Shah et al., Gastroenterology 1999 (Liver Cirrhosis, Experimental) : These studies provide evidence that enhanced expression and interaction of caveolin with eNOS contribute to impaired NO production, reduced NOS activity, and vasoconstriction in the intact cirrhotic liver
Shah et al., Am J Physiol Gastrointest Liver Physiol 2001 (Hypertension, Portal) : The purpose of this study is to characterize the expression and cellular localization of the NOS inhibitory protein caveolin-1 in normal rat liver and to then examine the role of caveolin in conjunction with calmodulin in regulation of NOS activity in cholestatic portal hypertension ... We conclude that, in cholestatic portal hypertension, caveolin may negatively regulate NOS activity in a manner that is reversible by excess calmodulin
Aravamudan et al., Hum Mol Genet 2003 (Muscular Dystrophies...) : In addition, we demonstrate that the activity of nitric oxide synthase (NOS) is down-regulated by high levels of caveolin-3 in the heart
Sbaa et al., Trends Cardiovasc Med 2005 : The double regulation of endothelial nitric oxide synthase by caveolae and caveolin : a paradox solved through the study of angiogenesis
Rasmusen et al., Ann Biol Clin (Paris) 2005 (Atherosclerosis...) : The co-operation between cholesterol synthesis and the upregulation of caveolin-1 on the one hand, and the activation of endothelial nitric oxide synthase on the other hand, is very tight
Shen et al., J Neurochem 2006 (Brain Ischemia...) : Exposure to 1 h ischemia induced the increases in neuronal nitric oxide synthase (nNOS) and NO concentration with concurrent down-regulation of caveolin-1 expression in the ischemic core of rat brains
Krasteva et al., Int J Biochem Cell Biol 2007 : Since caveolin-1 is found only in a subpopulation of ciliated cells at the basolateral cell membrane, we examined if caveolin-3 could be responsible for the apical localization of endothelial nitric oxide synthase in ciliated cells
Suh et al., J Korean Med Sci 2010 (Hypertension) : HMG-CoA reductase inhibitor improves endothelial dysfunction in spontaneous hypertensive rats via down-regulation of caveolin-1 and activation of endothelial nitric oxide synthase
Schreihofer et al., Vascul Pharmacol 2010 : These data suggest that HS diets have no effect on vascular NO production, and that E2 may modulate basal NO production by reducing the expression of caveolin-1 , an allosteric inhibitor of NOS activity
Dessy et al., Pflugers Arch 2010 : The regulation of endothelial nitric oxide synthase by caveolin : a paradigm validated in vivo and shared by the ` endothelium derived hyperpolarizing factor '
Tian et al., Free Radic Biol Med 2010 : A novel role for caveolin-1 in regulating endothelial nitric oxide synthase activation in response to H2O2 and shear stress
Adebola et al., Afr Health Sci 2011 : Nitric oxide synthase (NOS) is negatively regulated by protein-protein interactions with caveolin-1 before extracellular activating signals release it for nitric oxide ( NO ) production ... We conclude that unlike caveolin-1 , a known pre-activation inhibitor of nascent NOS , PKG may be a post-activation inhibitor of NOS, possibly important for the recycling of the spent enzyme
Cheng et al., J Mol Cell Cardiol 2013 : Based on these findings, we hypothesized that an nNOS complex mediated the effect of Cav3 on SCN5A
Michel et al., J Biol Chem 1997 : Reciprocal regulation of endothelial nitric-oxide synthase by Ca2+-calmodulin and caveolin
Feron et al., Biochemistry 1998 : Dynamic regulation of endothelial nitric oxide synthase : complementary roles of dual acylation and caveolin interactions