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CAV3 — NOS1
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
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Gene Ontology Complexes protein complex:
protein complex complex (HSF1-TRMT112-HIST1H4A-UBQLN1-CDX2-USP28-HDAC5-CAV3-CANX-LHX1-TUBA3C-TUBA3E-PI4K2A-NR0B2-RYR2-NTRK1-MPP5-N6AMT1-STAP1-ZFP42-FADD-ATP6V0D1-PRKCDBP-AQP2-FNTB-PRPSAP2-WIPI2-CRB3-CRB2-PEX11A-LDB1-RBP4-TMEM102-GATA2-ADCY2-DZIP1-SYK-TUBB4B-PTPN11-KAT5-CEP290-SYP-ASF1B-PLEKHA2-KIF24-MYO5B-RGP1-CFTR-SPTBN5-VPS72-ACTA2-PRKCI-CNST-SNX4-GNAO1-NFKBIA-UBE2D2-EPB41-RAB5A-GLUL-BSND-GSK3B-SKI-XRCC6-PPM1E-TTR-TUBA1A-SUCLG1-TRIAP1-AKT1S1-MYD88-NPPB-GDF11-INCENP-PLCB3-BECN1-PRKAB1-SOD1-TUBB1-NPHS2-NPHS1-EPS8L1-GDI1-TUBB2A-TUBB2B-SUCLG2-PEX3-TUBAL3-ERLIN1-MAGED1-GCH1-TUBB-CPS1-MEF2C-ZNF703-SLC22A6-CPLX1-EIF4EBP1-TUBE1-FLNA-CD19-STX1A-HDAC2-TOMM40L-HDAC6-SMAD6-SMAD7-TLE6-SMAD2-PARD6B-STXBP1-ACR-TRPC1-PARD6A-TRPC4-PANX1-DCTN1-SOX9-PXMP2-BCR-SET-MALT1-BHMT-RILP-TRADD-HIST1H3A-MAPK1-PVALB-NFKB1-NUFIP1-ACVR2B-TAL1-FOXP3-SSX2IP-GNB2-SLC27A5-GOPC-PAX2-CXADR-AIF1L-APBA1-MYL12A-LMO2-ID2-CCDC113-DDOST-SPP2-GATAD2B-PLN-ERCC8-BIRC8-ASF1A-CAB39-BIRC3-BIRC2-CTNNB1-CORO1A-PRELID1-HAND2-CHAF1B-SCAP-GNAT3-CDC20-SMARCA4-IQGAP1-YWHAZ-CEBPA-PRPS2-AXIN1-XRCC5-YWHAQ-UVRAG-SLC51B-RGS4-RGS6-HTT-YWHAB-APCS-CDCA8-RIPK1-MTA2-SIN3A-ANXA1-NOS1-SNTA1-TRAF6-KPNB1-VCL-VCP-PTRF-PRKCZ-SKIL-RAB3A-KRIT1-SSBP3-PRPSAP1-PPP1CC-TAB1-MYO6-ACTL7A-TUBG2-MBD2-COL6A1-COL6A2-BCL3)
Helps et al., Biochem J 2000, Lauderdale et al., Proc Natl Acad Sci U S A 2000, Didichenko et al., FEBS Lett 2000, Koh et al., Curr Biol 2002, Fan et al., Mol Cell Biol 2002, Groisman et al., Cell 2003, Offenhäuser et al., Mol Biol Cell 2004, Tagami et al., Cell 2004, Doyon et al., Mol Cell Biol 2004, Moore et al., Genomics 2004, Sun et al., Mol Cell 2004, Zang et al., J Cell Biochem 2004, Tian et al., Cancer Res 2005, An et al., Biochemistry 2005, Mahajan et al., Proc Natl Acad Sci U S A 2005, Vader et al., EMBO Rep 2006, Yeh et al., J Biol Chem 2006, Li et al., Immunol Rev 2006, Agbas et al., Biochem J 2007, Swiatecka-Urban et al., J Biol Chem 2007, McKeegan et al., Mol Cell Biol 2007, Shono et al., J Am Soc Nephrol 2007, Popov et al., Cell cycle (Georgetown, Tex.) 2007, Sato et al., J Biol Chem 2008, Fitzgerald et al., J Biol Chem 2008, Lyssand et al., J Biol Chem 2008, Figaro et al., FEBS Lett 2008, Ueda et al., Proc Natl Acad Sci U S A 2008, Shimojo et al., J Biol Chem 2008, Costantini et al., Blood 2009, Mitsuishi et al., J Biol Chem 2010, Masuda et al., J Biol Chem 2010, Koch et al., J Cell Sci 2010, Boëda et al., J Biol Chem 2011, Sircoulomb et al., EMBO Mol Med 2011, Hoxhaj et al., J Cell Sci 2012, Uckun et al., Proc Natl Acad Sci U S A 2012, Pusapati et al., J Biol Chem 2012, Ghai et al., Proc Natl Acad Sci U S A 2013, Kelly et al., PLoS Biol 2013, Chiang et al., PloS one 2013, Dauphinee et al., J Immunol 2013, Potting et al., Cell Metab 2013, Ludwig et al., PLoS Biol 2013, Lee et al., Proc Natl Acad Sci U S A 2013, Kobayashi et al., J Cell Biol 2014, Zheng et al., Am J Physiol 1994, Kumar et al., Biochem Biophys Res Commun 1998, Watabe-Uchida et al., J Cell Biol 1998, Haft et al., Mol Cell Biol 1998
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IRef Hprd Interaction:
NOS1
—
CAV3
(in vitro)
Venema et al., J Biol Chem 1997*
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IRef Ophid Interaction:
NOS1
—
CAV3
(aggregation, confirmational text mining)
Venema et al., J Biol Chem 1997*
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IRef Ophid Interaction:
NOS1
—
CAV3
(aggregation, interologs mapping)
Brown et al., Bioinformatics 2005
Text-mined interactions from Literome
Shah et al., Gastroenterology 1999
(Liver Cirrhosis, Experimental) :
These studies provide evidence that enhanced expression and interaction of
caveolin with eNOS
contribute to impaired NO production, reduced
NOS activity, and vasoconstriction in the intact cirrhotic liver
Shah et al., Am J Physiol Gastrointest Liver Physiol 2001
(Hypertension, Portal) :
The purpose of this study is to characterize the expression and cellular localization of the NOS inhibitory protein caveolin-1 in normal rat liver and to then examine the
role of
caveolin in conjunction with calmodulin in regulation of
NOS activity in cholestatic portal hypertension ... We conclude that, in cholestatic portal hypertension,
caveolin may negatively
regulate NOS activity in a manner that is reversible by excess calmodulin
Aravamudan et al., Hum Mol Genet 2003
(Muscular Dystrophies...) :
In addition, we demonstrate that the activity of
nitric oxide synthase (NOS) is
down-regulated by high levels of
caveolin-3 in the heart
Sbaa et al., Trends Cardiovasc Med 2005
:
The double
regulation of endothelial
nitric oxide synthase by caveolae and
caveolin : a paradox solved through the study of angiogenesis
Rasmusen et al., Ann Biol Clin (Paris) 2005
(Atherosclerosis...) :
The co-operation between cholesterol synthesis and the upregulation of
caveolin-1 on the one hand, and the
activation of endothelial
nitric oxide synthase on the other hand, is very tight
Shen et al., J Neurochem 2006
(Brain Ischemia...) :
Exposure to 1 h ischemia
induced the increases in
neuronal nitric oxide synthase (nNOS) and NO concentration with concurrent down-regulation of
caveolin-1 expression in the ischemic core of rat brains
Krasteva et al., Int J Biochem Cell Biol 2007
:
Since caveolin-1 is found only in a subpopulation of ciliated cells at the basolateral cell membrane, we examined if
caveolin-3 could be
responsible for the apical localization of endothelial
nitric oxide synthase in ciliated cells
Suh et al., J Korean Med Sci 2010
(Hypertension) :
HMG-CoA reductase inhibitor improves endothelial dysfunction in spontaneous hypertensive rats via down-regulation of
caveolin-1 and
activation of endothelial
nitric oxide synthase
Schreihofer et al., Vascul Pharmacol 2010
:
These data suggest that HS diets have no effect on vascular NO production, and that E2 may modulate basal NO production by reducing the expression of
caveolin-1 , an allosteric
inhibitor of
NOS activity
Dessy et al., Pflugers Arch 2010
:
The
regulation of endothelial
nitric oxide synthase by
caveolin : a paradigm validated in vivo and shared by the ` endothelium derived hyperpolarizing factor '
Tian et al., Free Radic Biol Med 2010
:
A novel
role for
caveolin-1 in regulating endothelial
nitric oxide synthase activation in response to H2O2 and shear stress
Adebola et al., Afr Health Sci 2011
:
Nitric oxide synthase (NOS) is negatively
regulated by protein-protein interactions with
caveolin-1 before extracellular activating signals release it for nitric oxide ( NO ) production ... We conclude that unlike
caveolin-1 , a known pre-activation
inhibitor of nascent
NOS , PKG may be a post-activation inhibitor of NOS, possibly important for the recycling of the spent enzyme
Cheng et al., J Mol Cell Cardiol 2013
:
Based on these findings, we hypothesized that an
nNOS complex
mediated the effect of
Cav3 on SCN5A
Michel et al., J Biol Chem 1997
:
Reciprocal
regulation of endothelial
nitric-oxide synthase by Ca2+-calmodulin and
caveolin
Feron et al., Biochemistry 1998
:
Dynamic regulation of endothelial
nitric oxide synthase : complementary
roles of dual acylation and
caveolin interactions