Gene interactions and pathways from curated databases and text-mining

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AKT1 — CAV3

Text-mined interactions from Literome

Sedding et al., Circ Res 2005 : Furthermore, caveolin-1 is essential for the integrin mediated activation of PI3-K/Akt
Oh et al., J Cell Biochem 2006 : However in contrast to adipocytes, phosphorylation of insulin receptor beta (IRbeta) and Akt/Erk was not affected by the respective downregulation of caveolin-1 or caveolin-3 in the muscle cells
Albinsson et al., Am J Physiol Cell Physiol 2008 (Hypertrophy...) : In conclusion, caveolin 1 contributes to low basal ERK1/2 and Akt activity and is required for Akt dependent signals in response to shear stress ( flow ) but is not essential for trophic effects of stretch ( pressure ) in the vascular wall
Tian et al., J Biol Chem 2009 : Mechanistically, both Src and caveolin-1 are required for ouabain induced activation of Akt and up-regulation of Na/K-ATPase
Park et al., Am J Physiol Cell Physiol 2009 : Especially, phosphorylation of caveolin-1 is attenuated by AG1478, herbimycin A ( tyrosine kinase inhibitors ), and pyrazolopyrimidine 2 ( PP2, Src inhibitor ) and EGF induced ERK activation was blocked by PP2, methyl-beta-cyclodextrin ( MbetaCD ), caveolin-1 small interfering RNA ( siRNA ), LY-294002 [ phosphoinositol-3 kinase inhibitor ( PI3K ) ], and Akt inhibitor
Xia et al., Am J Pathol 2010 (Idiopathic Pulmonary Fibrosis) : We demonstrate that caveolin-1 expression is low in IPF fibroblasts and that this correlates with low membrane PTEN levels, whereas overexpression of caveolin-1 restores membrane PTEN levels, inhibits Akt phosphorylation, and suppresses proliferation
Meyer et al., J Hepatol 2011 : In contrast, non-Smad/AKT pathway activation required functional dynamin mediated endocytosis and the presence of caveolin-1 , an essential protein for caveolae formation
Feng et al., J Cell Physiol 2012 : Downregulation of caveolin-1 significantly attenuated the FGF2 induced activation of AKT1 and ERK1/2 and inhibited FGF2 induced cell proliferation, migration and tube formation in oFPAE cells
Huang et al., FASEB J 2011 : Exposure to HIV-1 infected monocytes induced phosphorylation of ERK1/2 and Akt in hCMEC by 2.5- and 3.6-fold, respectively ; however, these effects were attenuated by overexpression of PPARa or PPAR? and by silencing of caveolin-1 ( cav-1 )
Basu Roy et al., Int J Cancer 2013 (Cell Transformation, Neoplastic...) : Increased AKT signaling induces caveolin-1 expression by increasing the activity of the transcription factor, Sp1
Nho et al., PloS one 2013 (Idiopathic Pulmonary Fibrosis) : We demonstrate that PTEN over-expression or Akt inhibition increases FoxO3a expression in IPF fibroblasts, resulting in up-regulation of caveolin-1