Gene interactions and pathways from curated databases and text-mining

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CAV2 — IGF1

Text-mined interactions from Literome

Maggi et al., Biochem Biophys Res Commun 2002 : IGF-I induces caveolin 1 tyrosine phosphorylation and translocation in the lipid rafts
Podar et al., J Biol Chem 2003 (Multiple Myeloma) : Interleukin-6 and insulin-like growth factor-I , growth and survival factors in multiple myeloma, induce caveolin-1 phosphorylation, which is abrogated by pre-treatment with beta-cyclodextrin
Panetta et al., Biochem Biophys Res Commun 2004 : IGF-I regulates caveolin 1 and IRS1 interaction in caveolae
Repetto et al., Biochem Biophys Res Commun 2005 : Since Insulin and IGF-I phosphorylate and activate eNOS, we investigated the role of caveolin-1 in Insulin and IGF-I stimulated eNOS activity ... These results suggest that caveolae could represent an intracellular site that contributes to differentiate IR and IGF-IR activity, and demonstrate the role of caveolin-1 in the eNOS activation by Insulin and IGF-I
Matthews et al., Endocrinology 2008 : Modulation of caveolin-1 expression can affect signalling through the phosphatidylinositol 3-kinase/Akt pathway and cellular proliferation in response to insulin-like growth factor I ... Interestingly, IGF-I induced proliferation was similar in MF ( -/- ) and MF ( +/+ ) cells, whereas caveolin-1 knockdown promoted a hyperproliferative response to IGF-I [ pkDCav3T3L1 ( 80 ) 12.4+/-0.4-fold ; pkDShuffle3T3L1 4.3+/-0.2-fold induction ; P < 0.01 ] ... Interestingly, IGF-I induced proliferation was similar in MF ( -/- ) and MF ( +/+ ) cells, whereas caveolin-1 knockdown promoted a hyperproliferative response to IGF-I [ pkDCav3T3L1 ( 80 ) 12.4+/-0.4-fold ; pkDShuffle3T3L1 4.3+/-0.2-fold induction ; P < 0.01 ]