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CAV1 — IGF2

Text-mined interactions from Literome

Glait et al., Exp Cell Res 2006 (Breast Neoplasms) : In addition, we demonstrated that transcriptional activation of the IGF-IR gene by Cav-1 requires an intact p53 signaling pathway, since Cav-1 was unable to elevate IGF-IR levels in p53-null cells
Salani et al., Endocrinology 2008 : To determine the role of Cav-1 in IGF-IR signaling, we transfected H9C2 cells with small interfering RNA specific for Cav-1-siRNA ... These results demonstrate that : 1 ) Cav-1 down-regulation negatively affects IGF-IR tyrosine phosphorylation ; 2 ) this effect causes a reduced activation of insulin receptor substrate-1, Shc, and Akt ; and 3 ) Cav-1 is involved in IGF-IR antiapoptotic signaling after serum deprivation
Matthews et al., Endocrinology 2008 : Interestingly, IGF-I induced proliferation was similar in MF ( -/- ) and MF ( +/+ ) cells, whereas caveolin-1 knockdown promoted a hyperproliferative response to IGF-I [ pkDCav3T3L1 ( 80 ) 12.4+/-0.4-fold ; pkDShuffle3T3L1 4.3+/-0.2-fold induction ; P < 0.01 ]