Gene interactions and pathways from curated databases and text-mining

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CASP9 — IL5

Text-mined interactions from Literome

Létuvé et al., J Leukoc Biol 2001 (Hypereosinophilic Syndrome...) : Interleukin (IL)-5 and interferon (IFN)-gamma, two cytokines known to prolong eosinophil survival, inhibited Fas mediated apoptosis and caspase activation but poorly affected the decrease in DeltaPsi ( m )
Guo et al., Blood 2003 : In the present study we confirm that Fas signaling induces both phenotypic and functional maturation of murine DCs, and we demonstrate that phenotypic maturation is associated with phosphorylation of extracellular signal regulated kinase ( ERK ) 1/2, activation of caspase-1 , and secretion of interleukin-beta ( IL-1beta )
Wang et al., Ann Thorac Surg 2005 (Reperfusion Injury) : Myocardial tissue was then assessed for products of p38 MAPK activation, expression of tumor necrosis factor, interleukin-1beta and interleukin-6, and activation of caspase-1, caspase-3 and caspase-11
Shushanov et al., Bull Exp Biol Med 2010 : Insulin-like growth factor-1 and insulin inhibit caspase-3/7 activation initiated by interleukin-1ß in the rat eye retinal neurons
Liao et al., Inflamm Res 2013 : Lipopolysaccharide/adenosine triphosphate mediated signal transduction in the regulation of NLRP3 protein expression and caspase-1 mediated interleukin-1ß secretion
Kano et al., J Allergy Clin Immunol 2013 : Paradoxically, Siglec-8 mediated cell death is markedly enhanced by the presence of the activation and survival factor IL-5 and becomes independent of caspase activity