Gene interactions and pathways from curated databases and text-mining

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CASP8 — CHUK

Pathways - manually collected, often from reviews:

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

Text-mined interactions from Literome

Chen et al., Crit Care Med 2007 (Burns...) : IKK blocks caspase 3 expression by up-regulating BCL-xL and cellular FLICE inhibitory protein expression
Oh et al., J Pharmacol Exp Ther 2011 (Inflammation...) : In activated human mast cells, the receptor interacting protein 2 (RIP2), I?B kinase ( IKK ) -ß, nuclear factor-?B ( NF-?B ) /RelA, and caspase-1 activation were increased, but increased RIP2, IKK-ß , NF-?B/RelA, and caspase-1 activation were inhibited by the treatment of IPT