Gene interactions and pathways from curated databases and text-mining

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CASP6 — CREB1

Text-mined interactions from Literome

Rabelo et al., Biochem Biophys Res Commun 2003 (Fibrosarcoma) : The butyrate effect was shown to be dependent on caspase activation, once caspase inhibitors restored phosphorylation of ERK1/2 and CREB in 2C4 cells
Lee et al., Toxicol Appl Pharmacol 2003 : 2,2',4,6,6'-pentachlorobiphenyl ( PCB 104 ) induces apoptosis of human microvascular endothelial cells through the caspase dependent activation of CREB
Jover-Mengual et al., Endocrinology 2007 (Ischemia...) : We demonstrate that global ischemia promotes early dephosphorylation and inactivation of ERK1 and the transcription factor cAMP-response element binding protein ( CREB ), subsequent down-regulation of the antiapoptotic protein Bcl-2, a known gene target of estradiol and CREB , and activation of caspase-3
Sarkar et al., Diabetologia 2007 (Cadaver) : Expression of CREB mutants in human islets resulted in significant ( p < 0.001 ) activation of caspase-9 , a key regulatory enzyme in the mitochondrial pathway of apoptosis, when compared with islets transduced with adenoviral beta galactosidase
Ghorpade et al., Mol Cell Biol 2012 : The miR-155 triggered activation of caspase-3 , BAK1, and cytochrome c translocation involved signaling integration of MAPKs and epigenetic or posttranslational modification of histones or CREB