Gene interactions and pathways from curated databases and text-mining

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CANX — IGF1

Text-mined interactions from Literome

Grzelkowska-Kowalczyk et al., Cell Mol Biol Lett 2010 : Pretreatment of myogenic cells with IL-1beta did not modify the IGF-I stimulated phosphorylation of PKB, p70 ( S6k ), p42(MAPK) and p90 ( rsk )
Thimmaiah et al., Cancer Res 2010 (Rhabdomyosarcoma) : Results indicate that IGF-I signaling to Bad requires activation of PI3K and PKC ( mu, theta, epsilon ) but not mTOR, Ras-extracellular signal regulated kinase 1/2, protein kinase A, or p90 ( RSK )
Zoubeidi et al., Cancer Res 2010 (MAP Kinase Signaling System...) : Hsp27 overexpression increases IGF-I induced phosphorylation of Erk, p90Rsk , and Akt ... Conversely, Hsp27 knockdown abrogates IGF-I induced phosphorylation of Erk, p90Rsk , and Akt, thereby destabilizing Bad/14-3-3 complexes and increasing apoptotic rates