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CAMK1 — CREB1
Pathways - manually collected, often from reviews:
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OpenBEL Selventa BEL large corpus:
CREB1
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CAMK1
(directlyIncreases, CAMK1 Activity, CREB1 Activity)
Evidence: The substrate preferences of CaMKI and CaMKIV are similar and intersect with CaMKII. In vitro, all three can phosphorylate synapsin I, cAMP response element-binding protein (CREB), and activating transcription factor 1 (11, 12).
Text-mined interactions from Literome
Hansen et al., J Neurosci Res 2003
(Calcium Signaling) :
First, that depolarization of SGNs activates CaMKs is evidenced by observation of increased CaMKII phosphorylation and of
CaMK dependent
CREB phosphorylation
Ahi et al., Behav Brain Res 2004
:
Inhibition of
CaMK II did not affect fear conditioning and
reduced the phosphorylation of Erk-1/2, Elk-1,
CREB , and p90Rsk-1 only transiently, whereas Mek-1/2 inhibition was ineffective in all experiments
Egan et al., Cell Signal 2004
:
In contrast,
CREB activation induced by depolarization in both neonatal and developed VSM was significantly
reduced by
CaMK inhibition and by ERK1/2 inhibition
Mathieson et al., Br J Pharmacol 2006
:
CREB activation by SPC
required both p38MAPK and
CaMK activation, but not ERK1/2
Francis et al., Am J Physiol Cell Physiol 2008
:
In several cells : 1 ) activation of HRH1 increases intracellular Ca ( 2+ ) concentration levels ; and 2 ) increased [ Ca ( 2+ ) ] ( i ) levels are coupled with calmodulin dependent stimulation of calmodulin dependent protein kinase (
CaMK ) and
activation of cAMP-response element binding protein (
CREB ) ... We measured IP ( 3 ), Ca ( 2+ ) and cAMP levels, phosphorylation of
CaMK I , and
activation of
CREB ( in the absence/presence of W7 ) in small cholangiocytes treated with HTMT dimaleate
Sasaki et al., Neuron 2011
:
These findings suggest that SIK2 plays critical roles in neuronal survival, is modulated by
CaMK I/IV , and
regulates CREB via TORC1
Houglum et al., J Clin Invest 1997
:
Moreover, the phosphorylation of
CREB on Ser133 was
stimulated in activated cells by inducing the activity of PKA or
CAMK-II