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AKT1 — CALM3
Text-mined interactions from Literome
Okuno et al., J Biochem 2000
:
Besides CaM-kinase kinase alpha,
CaM-kinase II also remarkably
activated PKB
Egea et al., J Cell Biol 2001
:
In this report, we have analyzed the
involvement of Ca2+ and
calmodulin (CaM) in the activation of the
PKB induced by NTs ... We have investigated the mechanisms whereby
CaM regulates the activation of the
PKB , and we have found that CaM was necessary for the proper generation and/or accumulation of the products of the PI 3-kinase in intact cells
Chen et al., J Biol Chem 2002
:
Calcium/calmodulin dependent protein kinase kinase ( CaMKK ) and
Akt are two multifunctional kinases involved in many cellular responses
Verploegen et al., Eur J Biochem 2002
(Calcium Signaling) :
Inhibition of
calmodulin using a calmodulin antagonist N- ( 6-aminohexyl ) -5-chloro-1-naphthalenesulfonamide ( W7 ), did not effect N-formyl-methionyl-leucyl-phenylalanine ( fMLP ) induced ERK, p38 MAPK or GSK-3alpha phosphorylation, but
attenuated fMLP induced
PKB phosphorylation
Bae et al., Biochem Biophys Res Commun 2003
:
This acute effect of BK on both increases was blocked only by treatment of protein kinase A inhibitor H-89, but not by the inhibitors of
calmodulin dependent kinase II and
protein kinase B , suggesting that the rapid increase in NO production by BK is mediated by the PKA dependent phosphorylation of eNOS-Ser ( 1179 )
Spicer et al., Endocr Pathol 2003
:
Research over the last few years has revealed that the hypoxia response in PC12 cells involves the interactions of several signal transduction pathways (
Ca2+/calmodulin dependent kinases,
Akt , SAPKs, and MAPKs ) and transcription factors ( HIFs, CREB, and c-fos/junB )
Deb et al., J Biol Chem 2004
:
Calmodulin mediated activation of
Akt regulates survival of c-Myc overexpressing mouse mammary carcinoma cells ... We now demonstrate that EGF induced
Akt activation and survival in transgenic mouse mammary tumor virus-c-Myc mouse mammary carcinoma cells are both
calcium/calmodulin dependent ... EGF induced and
calcium/calmodulin mediated
Akt activation occurs in both tumorigenic and non-tumorigenic mouse and human mammary epithelial cells, independent of their overexpression of c-Myc
Yano et al., J Pharmacol Sci 2005
(Brain Ischemia) :
We here observed that
CaM-KK could directly
activate Akt , thereby preventing apoptosis in cultured cells
Siarey et al., J Neurochem 2006
(Down Syndrome) :
Here we report that
calcium/calmodulin dependent protein kinase II ( CaMKII ), phosphatidylinositol 3-kinase
(PI3K)/Akt , extracellular signal regulated kinase ( ERK ), protein kinase A (PKA) and protein kinase C ( PKC ), all of which have been shown to be involved in synaptic plasticity, are altered in the Ts65Dn hippocampus
Lahair et al., Antioxid Redox Signal 2006
:
In contrast, hydrogen peroxide induced phosphorylation of Akt on serine 473 ( S473 ) was downregulated by both PI3K and CaM-K inhibition, indicating that hydrogen peroxideinduced phosphorylation of
Akt on S473 was largely
dependent on both PI3K and a
CaM-K activity
Xu et al., Hippocampus 2007
(Brain Infarction...) :
Subtoxic N-methyl-D-aspartate delayed neuronal death in ischemic brain injury through TrkB receptor- and
calmodulin mediated
PI-3K/Akt pathway activation ... W-13, an active CaM inhibitor, prevented the combination of
CaM and p85 and subsequent
Akt activation
Coticchia et al., Breast Cancer Res Treat 2009
(Breast Neoplasms) :
Suppression of
calmodulin expression by siRNAs against all three calmodulin genes in c-Myc overexpressing mouse mammary carcinoma cells
results in significant inhibition of EGF induced
Akt activation ... However, forced overexpression of either epidermal growth factor receptor (EGFR) or ErbB2 did partially restore
calmodulin dependent EGF stimulated
Akt activation ... In an attempt to address how
calmodulin is
regulating Akt activity, we looked at localization of fluorescently tagged Akt and calmodulin in MCF-7 and SK-BR-3 cells ... Thus,
calmodulin may be
regulating Akt activity by modulating its sub-cellular location and is a novel target in the poor prognosis, ER-negative subset of breast cancers
Bouallegue et al., Free Radic Biol Med 2009
:
We have shown earlier a
requirement for Ca ( 2+ ) and
calmodulin (CaM) in the H ( 2 ) O ( 2 ) -induced activation of extracellular signal regulated kinases 1 and 2 ( ERK1/2 ) and
protein kinase B (PKB) , key mediators of growth promoting, proliferative, and hypertrophic responses in vascular smooth muscle cells ( VSMC )
Song et al., J Biol Chem 2010
:
We found that Ser-21/9 phosphorylation of GSK-3 was mediated by Ca ( 2+ )
/calmodulin dependent protein kinase II ( CaMKII ) but not by
Akt/PKB , PKA, or p90 ( RSK ) ... We found that Ser-21/9 phosphorylation of GSK-3 was mediated by Ca ( 2+ )
/calmodulin dependent protein kinase II ( CaMKII ) but not by
Akt/PKB , PKA, or p90 ( RSK )
O'Neill et al., Theriogenology 2012
:
These mediators act via 1-o-phosphatidylinositol-3-kinase signaling which has the dual effects of activating
calcium/calmodulin dependent kinase/CREB transcription factor and
AKT ( protein kinase B ) /MDM2 mediated survival pathways
Han et al., Mol Nutr Food Res 2012
:
Moreover, capsaicin increased the activation of the transient receptor potential vanilloid type-1 receptor downstream signaling components
Ca²?/calmodulin dependent protein kinase and
Akt
Cao et al., PLoS Biol 2013
(Angelman Syndrome) :
In Ube3A deficient mice, the BDNF induced recruitment of PSD-95, as well as PLC? and Grb2 associated binder 1 (Gab1) with TrkB receptors was attenuated, resulting in reduced activation of
PLC?-a-calcium/calmodulin dependent protein kinase II ( CaMKII ) and
PI3K-Akt , but leaving the extracellular signal regulated kinase ( Erk ) pathway intact
Farrer et al., J Biol Chem 2013
(Neurofibromatosis 1) :
Akt also co-immunoprecipitated with CaM in a PDGF-BB dependent manner, suggesting that direct interaction between Akt and
CaM is
involved in the sustained phosphorylation of
Akt
Yano et al., Nature 1998
:
These results identify a Ca2+ triggered signalling cascade in which
CaM-KK activates
PKB , which in turn phosphorylates BAD and protects cells from apoptosis