Gene interactions and pathways from curated databases and text-mining

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AKT1 — CALM3

Text-mined interactions from Literome

Okuno et al., J Biochem 2000 : Besides CaM-kinase kinase alpha, CaM-kinase II also remarkably activated PKB
Egea et al., J Cell Biol 2001 : In this report, we have analyzed the involvement of Ca2+ and calmodulin (CaM) in the activation of the PKB induced by NTs ... We have investigated the mechanisms whereby CaM regulates the activation of the PKB , and we have found that CaM was necessary for the proper generation and/or accumulation of the products of the PI 3-kinase in intact cells
Chen et al., J Biol Chem 2002 : Calcium/calmodulin dependent protein kinase kinase ( CaMKK ) and Akt are two multifunctional kinases involved in many cellular responses
Verploegen et al., Eur J Biochem 2002 (Calcium Signaling) : Inhibition of calmodulin using a calmodulin antagonist N- ( 6-aminohexyl ) -5-chloro-1-naphthalenesulfonamide ( W7 ), did not effect N-formyl-methionyl-leucyl-phenylalanine ( fMLP ) induced ERK, p38 MAPK or GSK-3alpha phosphorylation, but attenuated fMLP induced PKB phosphorylation
Bae et al., Biochem Biophys Res Commun 2003 : This acute effect of BK on both increases was blocked only by treatment of protein kinase A inhibitor H-89, but not by the inhibitors of calmodulin dependent kinase II and protein kinase B , suggesting that the rapid increase in NO production by BK is mediated by the PKA dependent phosphorylation of eNOS-Ser ( 1179 )
Spicer et al., Endocr Pathol 2003 : Research over the last few years has revealed that the hypoxia response in PC12 cells involves the interactions of several signal transduction pathways ( Ca2+/calmodulin dependent kinases, Akt , SAPKs, and MAPKs ) and transcription factors ( HIFs, CREB, and c-fos/junB )
Deb et al., J Biol Chem 2004 : Calmodulin mediated activation of Akt regulates survival of c-Myc overexpressing mouse mammary carcinoma cells ... We now demonstrate that EGF induced Akt activation and survival in transgenic mouse mammary tumor virus-c-Myc mouse mammary carcinoma cells are both calcium/calmodulin dependent ... EGF induced and calcium/calmodulin mediated Akt activation occurs in both tumorigenic and non-tumorigenic mouse and human mammary epithelial cells, independent of their overexpression of c-Myc
Yano et al., J Pharmacol Sci 2005 (Brain Ischemia) : We here observed that CaM-KK could directly activate Akt , thereby preventing apoptosis in cultured cells
Siarey et al., J Neurochem 2006 (Down Syndrome) : Here we report that calcium/calmodulin dependent protein kinase II ( CaMKII ), phosphatidylinositol 3-kinase (PI3K)/Akt , extracellular signal regulated kinase ( ERK ), protein kinase A (PKA) and protein kinase C ( PKC ), all of which have been shown to be involved in synaptic plasticity, are altered in the Ts65Dn hippocampus
Lahair et al., Antioxid Redox Signal 2006 : In contrast, hydrogen peroxide induced phosphorylation of Akt on serine 473 ( S473 ) was downregulated by both PI3K and CaM-K inhibition, indicating that hydrogen peroxideinduced phosphorylation of Akt on S473 was largely dependent on both PI3K and a CaM-K activity
Xu et al., Hippocampus 2007 (Brain Infarction...) : Subtoxic N-methyl-D-aspartate delayed neuronal death in ischemic brain injury through TrkB receptor- and calmodulin mediated PI-3K/Akt pathway activation ... W-13, an active CaM inhibitor, prevented the combination of CaM and p85 and subsequent Akt activation
Coticchia et al., Breast Cancer Res Treat 2009 (Breast Neoplasms) : Suppression of calmodulin expression by siRNAs against all three calmodulin genes in c-Myc overexpressing mouse mammary carcinoma cells results in significant inhibition of EGF induced Akt activation ... However, forced overexpression of either epidermal growth factor receptor (EGFR) or ErbB2 did partially restore calmodulin dependent EGF stimulated Akt activation ... In an attempt to address how calmodulin is regulating Akt activity, we looked at localization of fluorescently tagged Akt and calmodulin in MCF-7 and SK-BR-3 cells ... Thus, calmodulin may be regulating Akt activity by modulating its sub-cellular location and is a novel target in the poor prognosis, ER-negative subset of breast cancers
Bouallegue et al., Free Radic Biol Med 2009 : We have shown earlier a requirement for Ca ( 2+ ) and calmodulin (CaM) in the H ( 2 ) O ( 2 ) -induced activation of extracellular signal regulated kinases 1 and 2 ( ERK1/2 ) and protein kinase B (PKB) , key mediators of growth promoting, proliferative, and hypertrophic responses in vascular smooth muscle cells ( VSMC )
Song et al., J Biol Chem 2010 : We found that Ser-21/9 phosphorylation of GSK-3 was mediated by Ca ( 2+ ) /calmodulin dependent protein kinase II ( CaMKII ) but not by Akt/PKB , PKA, or p90 ( RSK ) ... We found that Ser-21/9 phosphorylation of GSK-3 was mediated by Ca ( 2+ ) /calmodulin dependent protein kinase II ( CaMKII ) but not by Akt/PKB , PKA, or p90 ( RSK )
O'Neill et al., Theriogenology 2012 : These mediators act via 1-o-phosphatidylinositol-3-kinase signaling which has the dual effects of activating calcium/calmodulin dependent kinase/CREB transcription factor and AKT ( protein kinase B ) /MDM2 mediated survival pathways
Han et al., Mol Nutr Food Res 2012 : Moreover, capsaicin increased the activation of the transient receptor potential vanilloid type-1 receptor downstream signaling components Ca²?/calmodulin dependent protein kinase and Akt
Cao et al., PLoS Biol 2013 (Angelman Syndrome) : In Ube3A deficient mice, the BDNF induced recruitment of PSD-95, as well as PLC? and Grb2 associated binder 1 (Gab1) with TrkB receptors was attenuated, resulting in reduced activation of PLC?-a-calcium/calmodulin dependent protein kinase II ( CaMKII ) and PI3K-Akt , but leaving the extracellular signal regulated kinase ( Erk ) pathway intact
Farrer et al., J Biol Chem 2013 (Neurofibromatosis 1) : Akt also co-immunoprecipitated with CaM in a PDGF-BB dependent manner, suggesting that direct interaction between Akt and CaM is involved in the sustained phosphorylation of Akt
Yano et al., Nature 1998 : These results identify a Ca2+ triggered signalling cascade in which CaM-KK activates PKB , which in turn phosphorylates BAD and protects cells from apoptosis