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CA9 — HIF1A
Text-mined interactions from Literome
Grabmaier et al., Oncogene 2004
(Adenocarcinoma, Clear Cell...) :
Strict
regulation of
CAIX ( G250/MN ) by
HIF-1alpha in clear cell renal cell carcinoma
Berchner-Pfannschmidt et al., J Biol Chem 2004
(Anoxia) :
Herein, we investigated the
HIF-1alpha mediated gene expression of
carbonic anhydrase 9 (CA9) in response to hypoxia and changes of intracellular calcium levels in the neuroblastoma cell line SH-SY5Y
Hong et al., Lab Invest 2006
(Liver Diseases) :
Inactivation of the VHL gene resulted in hypoxia-inducible factor
(HIF)-1alpha stabilization and
induction of its target genes, VEGF and
CAIX , in mouse embryonic fibroblasts ( MEFs )
Birle et al., Cancer Res 2007
(Carcinoma, Squamous Cell...) :
Treatment with either drug produced accumulation of
HIF-1alpha in vitro but strongly
inhibited the production of
CAIX and vascular endothelial growth factor ( VEGF ) under hypoxia
Gauter-Fleckenstein et al., Free Radic Biol Med 2008
(Radiation Injuries...) :
However, at 16 weeks post-RT, only MnTE-2-PyP5+ at a dose of 6 mg/kg is able to ameliorate oxidative damage, block
activation of
HIF-1alpha and TGF-beta, and impair upregulation of
CA-IX and VEGF
Takacova et al., Oncol Rep 2010
:
Moreover, we demonstrate that Src mediated induction of
CA IX expression is critically
dependent on
HIF-1alpha activity