Gene interactions and pathways from curated databases and text-mining

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CA9 — HIF1A

Text-mined interactions from Literome

Grabmaier et al., Oncogene 2004 (Adenocarcinoma, Clear Cell...) : Strict regulation of CAIX ( G250/MN ) by HIF-1alpha in clear cell renal cell carcinoma
Berchner-Pfannschmidt et al., J Biol Chem 2004 (Anoxia) : Herein, we investigated the HIF-1alpha mediated gene expression of carbonic anhydrase 9 (CA9) in response to hypoxia and changes of intracellular calcium levels in the neuroblastoma cell line SH-SY5Y
Hong et al., Lab Invest 2006 (Liver Diseases) : Inactivation of the VHL gene resulted in hypoxia-inducible factor (HIF)-1alpha stabilization and induction of its target genes, VEGF and CAIX , in mouse embryonic fibroblasts ( MEFs )
Birle et al., Cancer Res 2007 (Carcinoma, Squamous Cell...) : Treatment with either drug produced accumulation of HIF-1alpha in vitro but strongly inhibited the production of CAIX and vascular endothelial growth factor ( VEGF ) under hypoxia
Gauter-Fleckenstein et al., Free Radic Biol Med 2008 (Radiation Injuries...) : However, at 16 weeks post-RT, only MnTE-2-PyP5+ at a dose of 6 mg/kg is able to ameliorate oxidative damage, block activation of HIF-1alpha and TGF-beta, and impair upregulation of CA-IX and VEGF
Takacova et al., Oncol Rep 2010 : Moreover, we demonstrate that Src mediated induction of CA IX expression is critically dependent on HIF-1alpha activity