Gene interactions and pathways from curated databases and text-mining

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CA2 — MAPK14

Text-mined interactions from Literome

Liu et al., Brain Res Mol Brain Res 1999 : All together, these results indicate that MAPK is implicated in the transmission of AMPA signaling to the nucleus and requires extracellular Ca2+ , and PLC/PKC activation
Zhang et al., J Immunol 1999 : However, p38 MAPK is activated strongly and synergistically by either CD3/CD28 coligation or PMA/Ca2+ ionophore stimulation, which mimics TCR-CD3/CD28 mediated signaling
Tauskela et al., Brain Res 1999 (Brain Ischemia...) : Ca2+ influx and activation of protein kinase C ( PKC ) and mitogen activated protein kinase ( MAPK ) during nonlethal ischemic preconditioning have been implicated in the protection of the heart against subsequent lethal ischemic injury
Huang et al., Cell Signal 1999 : Involvement of intermediary metabolites in the pathway of extracellular Ca2+ induced mitogen activated protein kinase activation in human fibroblasts ... Ca2+ induced MAPK activation was partly abolished by treatment of the cells with pertussis toxin
Wang et al., Mol Endocrinol 1999 (Pituitary Neoplasms) : These studies are consistent with a signaling pathway involving PKC- and Ca2+ dependent activation of MAPK , which leads to phosphorylation of an Ets transcription factor and activation of the PRL promoter
Huang et al., Eur J Biochem 1999 : Extra Ca2+ stimulated phosphorylation/activation of p42/p44 mitogen activated protein kinases by an initially ( 10 min ) zinc independent mechanism ; however, insulin, and particularly zinc, significantly prolonged Ca2+ induced mitogen activated protein kinase phosphorylation
Conrad et al., Adv Exp Med Biol 2000 : Role of Ca2+/CaM in the activation of MAPK and p38 gamma
Waltereit et al., J Neurosci 2001 : Arg3.1/Arc mRNA induction by Ca2+ and cAMP requires protein kinase A and mitogen activated protein kinase/extracellular regulated kinase activation
Fueta et al., Life Sci 2002 : Hyperexcitability and changes in activities of Ca2+/calmodulin dependent kinase II and mitogen activated protein kinase in the hippocampus of rats exposed to 1-bromopropane ... We studied whether the hyperexcitability is associated with changes of Ca2+/calmodulin dependent kinase II ( CaMKII ), mitogen activated protein kinase ( MAPK ), and protein kinase C ( PKC )
Schäfer et al., FASEB J 2003 (Calcium Signaling...) : Transient hypoxic inhibition of mitochondria induces a proliferative endothelial response mediated through Ca2+ independent activation and Ca2+ dependent nuclear translocation of p42 MAPK
Sorensen et al., Mol Pharmacol 2003 : Comparison of the intracellular signaling pathways of glial PAR-1, LPA, and S1P receptors indicates that each receptor class activates multiple downstream signaling pathways, including Gq/11 directed inositol lipid/Ca2+ signaling, Gi/o activation of mitogen activated protein kinases ( MAPK ) ( extracellular signal regulated kinase 1/2 and stress activated protein kinase/c-jun N-terminal kinase, but not p38 ), and activation of Rho pathways
Olszewska-Pazdrak et al., J Biol Chem 2004 : We report a novel mechanism for amplitude modulation of [Ca2+ ] ( i ) that involves mitogen activated protein kinase ( MAPK )
Ye et al., J Neurosci Res 2004 : Here we show that elevated Ca2+ ( o ) stimulates extracellular-signal regulated kinase ( ERK1/2 ) and p38 MAP kinase ( MAPK ) ... The effect of high Ca2+ ( o ) on p38 MAPK but not ERK1/2 is CaR mediated, insofar as transduction with a dominant negative CaR ( R185Q ) using recombinant adeno associated virus ( rAAV ) attenuated the activation of p38 MAPK but not of ERK1/2
Hilgenberg et al., J Neurobiol 2004 : Ca2+ release from intracellular stores activates both calcium/calmodulin dependent kinase II ( CaMKII ) and mitogen activated protein kinase ( MAPK )
Kim et al., Eur J Pharmacol 2005 (Hypertension) : Thus, basal vascular tone is elevated by the altered activation of MAPK in DOCA-salt hypertensive rats, and this is regulated by PKC, but not by Rho or intracellular Ca2+
Poeckel et al., J Pharmacol Exp Ther 2006 : 3-O-acetyl-11-keto-boswellic acid decreases basal intracellular Ca2+ levels and inhibits agonist induced Ca2+ mobilization and mitogen activated protein kinase activation in human monocytic cells
Kumada et al., J Neurosci 2006 (Disease Models, Animal...) : Each second messenger has multiple but distinct downstream targets, including Ca2+/calmodulin dependent protein kinase II, calcineurin, protein phosphatase 1, Rho GTPase, mitogen activated protein kinase , and phosphoinositide 3-kinase
Bourguignon et al., J Biol Chem 2006 (Carcinoma, Squamous Cell...) : Overexpression of the LARG-PDZ domain also functions as a dominant negative mutant ( similar to the PLC/Ca2+-calmodulin dependent kinase II ( CaMKII ) and EGFR/MAPK inhibitor effects ) to block HA/CD44 mediated signaling events ( e.g. EGFR kinase activation, Ras/RhoA co-activation, Raf-ERK signaling, PLC epsilon mediated inositol 1,4,5-triphosphate production, intracellular Ca2+ mobilization, CaMKII activity, filamin phosphorylation, and filamin-actin binding ) and to abrogate tumor cell growth/migration
Hodges et al., Invest Ophthalmol Vis Sci 2006 : Roles of protein kinase C, Ca2+ , Pyk2, and c-Src in agonist activation of rat lacrimal gland p42/p44 MAPK
Zhang et al., J Physiol 2007 : The effect was blocked by alpha7-nAChR antagonists, by chelation of intracellular Ca2+ with BAPTA, and by inhibition of both Ca2+-calmodulin dependent protein kinase II and mitogen activated protein kinase
Wang et al., J Biol Chem 2009 (Carcinoma, Hepatocellular) : Here we report that melittin can induce apoptosis of HCC cells by activating Ca2+/calmodulin dependent protein kinase, transforming growth factor-beta activated kinase 1 ( TAK1 ), and JNK/p38 MAPK
Donnellan et al., Am J Physiol Gastrointest Liver Physiol 2010 (MAP Kinase Signaling System) : These data demonstrate a novel role for JNK MAPK in regulating Ca2+ but not cAMP dependent epithelial Cl ( - ) secretion
Huang et al., Biochem J 1995 : Activation of MAPK by extracellular Ca2+ was dose dependent and biphasic, with a peak of activation at 5-10 min after exposure, followed by a period of sustained activation of MAPK at a lower level
Ito et al., Cell Growth Differ 1994 : The two putative isoforms of the cholecystokinin-B/gastrin receptor expressed in mouse fibroblasts showed the same characteristics in their ligand-bindings, the major signal transduction such as phosphoinositides production, cytoplasmic Ca2+ increase, tyrosine phosphorylation of focal adhesion kinase, activation of mitogen activated protein kinase , and the induction of early-responsive genes such as c-fos, c-myc, and c-jun
Hansen et al., J Biol Chem 1996 : Tyrosine phosphorylation was not required for GH stimulation of mitogen activated protein ( MAP ) kinase activity or for GH-stimulated Ca2+ channel activation since these pathways were normal in cells expressing a GH receptor in which all eight intracellular tyrosines were mutated to phenylalanines
Miralem et al., J Biol Chem 1996 : We conclude that heparin suppresses induction of c-fos in mesangial cells by blocking at least two different points in signal transduction cascades, one upstream of MAPK and the other independent of MAPK, but dependent on intracellular Ca2+
Duesbery et al., Zygote 1996 : The role of microtubules and inositol triphosphate induced Ca2+ release in the tyrosine phosphorylation of mitogen activated protein kinase in extracts of Xenopus laevis oocytes
Fiorucci et al., Gastroenterology 1996 : The aim of this study was to investigate whether EGF modulates pepsinogen release and intracellular Ca2+ concentrations ([Ca2+]i) and whether the effect involves mitogen activated protein ( MAP ) kinase , eicosanoid generation, and nitric oxide
Suzuki et al., Nihon Shinkei Seishin Yakurigaku Zasshi 1996 (Synaptic Transmission) : I review in this article the two groups of PSD proteins : Protein kinases ( Ca2+/calmodulin dependent protein kinase II, protein kinase C, mitogen activated protein kinase , and tyrosine kinases ) and molecules that work as messengers from the synapse to the nucleus ( MSNs )
Muthalif et al., J Biol Chem 1996 : We have investigated the contribution of Ca2+/calmodulin dependent protein kinase II ( CaM kinase II ) and mitogen activated protein kinase ( MAP kinase ) in norepinephrine ( NE ) -induced arachidonic acid ( AA ) release in rabbit aortic vascular smooth muscle cells ( VSMC )
Franklin et al., Am J Physiol 1997 : Eliminating extracellular Ca2+ had no effect on phorbol 12,13-dibutyrate ( PDBu ) -dependent contractions or MAPK activity ; however, KCl dependent contractions and MAPK activity were completely abolished by this procedure
Seewald et al., J Hypertens 1997 : The role of platelet derived growth factor-BB induced increase in cytosolic free Ca2+ in activation of mitogen activated protein kinase and DNA synthesis in vascular smooth muscle cells
Tian et al., Endocrinology 1998 : Although neither Ca2+ influx nor Ca2+ release from intracellular stores was sufficient to activate MAPK , Ca2+ appeared to play a permissive role in this response
Eguchi et al., J Biol Chem 1998 : We have recently reported that angiotensin II (Ang II) induced mitogen activated protein kinase ( MAPK ) activation is mainly mediated by Ca2+ dependent activation of a protein tyrosine kinase through Gq-coupled Ang II type 1 receptor in cultured rat vascular smooth muscle cells ( VSMC )
Wotta et al., Pharmacology 1998 : Activation of MAPK at the M1, M3 and M5 muscarinic receptor subtypes was not dependent on intracellular or extracellular Ca2+ , but was partially dependent upon protein kinase C
Samanta et al., J Neurochem 1998 : H2O2 alone strongly enhanced the levels of immunodetectable activated mitogen activated protein kinase ( activated MAP kinases ERK1 and ERK2 ) in a Ca2+ dependent manner and this effect was additive with increases in the levels of activated MAP kinase evoked by glutamate
Maulon et al., Blood 1998 : Our results are consistent with a negative role for p56Lck on thrombin induced [ Ca2+ ] i release and p38 MAPK activation in Jurkat T-cell lines
Zhang et al., J Physiol 1998 : Involvement of tyrosine kinases, Ca2+ and PKC in activation of mitogen activated protein ( MAP ) kinase in human polymorphonuclear neutrophils
Chin et al., Am J Physiol 1998 : SPC induced MAPK activation was blocked by treatment of cells with the phospholipase C inhibitor, U-73122, or the intracellular Ca2+-ATPase inhibitor, thapsigargin, but not by removal of extracellular Ca2+ ... Our results suggest that, in porcine aortic smooth muscle cells, MAPK is not activated by the increase in [ Ca2+ ] i unless a pertussis toxin-sensitive G protein is simultaneously stimulated, indicating the role of Ca2+ in pertussis toxin-sensitive G protein mediated MAPK activation