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C1QA — TLR4

Text-mined interactions from Literome

Yamada et al., Eur J Immunol 2004 : While C1q did not affect mRNA expression of Toll-like receptor 4 (TLR4) , MD-2, and myeloid differentiation factor 88 ( MyD88 ), BMDC treated with C1q showed the reduced activity of NF-kappaB and the delayed phosphorylation of p38, c-Jun N-terminal kinase, and extracellular signal regulated kinase after LPS-stimulation
Baruah et al., J Leukoc Biol 2006 : C1q increases the phagocytosis of apoptotic cells by DC and the release of interleukin-12 in the presence of TLR4 ligands and apoptotic cells ; PTX3 inhibits both events