Gene interactions and pathways from curated databases and text-mining

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BRAF — MAPK3

Pathways - manually collected, often from reviews:

Text-mined interactions from Literome

Dugan et al., J Biol Chem 1999 : Furthermore, constitutive expression of B-raf in astrocytoma cells increased MAPK activation, as seen in neurons, and enhanced proliferation
MacNicol et al., J Biol Chem 2000 : In Xenopus oocytes, the analogous full-length B-Raf 14-3-3 binding mutant blocked progesterone stimulated maturation and the activation of endogenous mitogen activated protein kinase kinase and mitogen activated protein kinase
Banihashemi et al., Mol Endocrinol 2002 : These results indicate that the dopamine-D2S receptor couples to distinct G ( i/o ) proteins, depending on the pathway addressed, and suggest a novel Galpha(i)3/Galpha ( o ) -dependent inhibition of MAPK mediated by c-Raf and B-Raf dependent inhibition of MAPK/ERK kinase
Yamaguchi et al., Kidney Int 2003 (MAP Kinase Signaling System...) : Inhibition of PKA by H89 strikingly decreased cAMP stimulated phosphorylation of ERK and B-Raf , and MAPK inhibition by PD98059 blocked the effect of the nucleotide to activate ERK
Namba et al., J Clin Endocrinol Metab 2003 (Carcinoma, Papillary...) : BRAF mutation associated enhanced cell growth was suppressed by MAPK kinase inhibitor, U0126
Trakul et al., J Biol Chem 2005 (MAP Kinase Signaling System) : Because c-Raf-1 and B-Raf are both required for maximal MAPK stimulation by epidermal growth factor in neuronal and epithelial cell lines, we determined whether RKIP significantly affects MAPK signaling
Mitsutake et al., Endocrinology 2006 (Carcinoma, Papillary...) : BRAF mediates RET/PTC induced mitogen activated protein kinase activation in thyroid cells : functional support for requirement of the RET/PTC-RAS-BRAF pathway in papillary thyroid carcinogenesis ... The requirement for BRAF in RET/PTC mediated MAPK activation and gene expression has not been tested functionally ... These data indicate that BRAF is required for RET/PTC induced MAPK activation in thyroid cells and support the notion that BRAF inactivation may be an attractive target for PTCs
Burger et al., Eur Urol 2006 (Microsatellite Instability...) : The present study investigated B-RAF mutations, MSI status, and activation of MAPK signaling in prostate tumors
Yue et al., Oncogene 2006 : No changes in the activity of B-Raf were detectable during progesterone induced oocyte maturation, after egg fertilization, or during the early embryonic cell cycle, arguing against a role for B-Raf in the mitotic activation of MEK1 and p42 MAPK ... We found that both B-Raf and C-Raf, but not Mos, are required for Ras induced MEK1 and p42 MAPK activation
Borysov et al., J Biol Chem 2006 : B-Raf is critical for MAPK activation during mitosis and is regulated in an M phase dependent manner in Xenopus egg extracts ... Furthermore suppression of MAPK feedback at mitosis enhanced B-Raf activity, whereas constitutive activation of MAPK at mitosis strongly suppressed B-Raf activity
Kono et al., Mol Cancer Res 2006 (MAP Kinase Signaling System...) : Because MAPK pathway activation via constitutively active mutant forms of BRAF is common in melanomas, correlation between BRAF function and antigen expression was investigated
Hao et al., Mol Cancer Ther 2007 (Colorectal Neoplasms...) : These observations suggest that inhibition of B-Raf activation of mitogen activated protein kinase ( MAPK ) /extracellular signal regulated kinase kinase ( MEK ) and the extracellular signal regulated kinase MAPK cascade may be an effective approach for the treatment of RAS and B-RAF mutation positive melanomas and colon carcinomas
Sheridan et al., J Biol Chem 2008 (Melanoma) : The majority of melanoma associated B-Raf mutations involve a single point mutation, V600E, which results in greatly elevated B-Raf kinase activity and constitutive activation of MAPK/ERK downstream
Knauf et al., Curr Opin Cell Biol 2009 (Disease Progression...) : In thyroid cancer, this interest is further heightened by new information on the role of activated BRAF and MAPK pathway activation in disrupting iodine transport and thyroid hormonogenesis
Pratilas et al., Clin Cancer Res 2010 (Neoplasms) : Mitogen activated protein kinase ( MAPK ) pathway activation is a frequent event in human cancer and is often the result of activating mutations in the BRAF and RAS oncogenes
Tartaglia et al., Molecular syndromology 2010 : SHP2 ( encoded by PTPN11 ), SOS1, BRAF , RAF1 and MEK1 positively contribute to RAS-MAPK signaling, and possess complex autoinhibitory mechanisms that are impaired by mutations
Gronych et al., J Clin Invest 2011 (Astrocytoma...) : Recent studies have identified activation of MAPK signaling, mainly by oncogenic BRAF activation, as a hallmark genetic event in the pathogenesis of human PA
Pratilas et al., Curr Top Microbiol Immunol 2012 : Mitogen Activated Protein Kinase ( MAPK ) pathway activation is a frequent event in human cancer and is often the result of activating mutations in the BRAF and RAS oncogenes
Lopez et al., Cell Death Differ 2012 (MAP Kinase Signaling System...) : Importantly, in a set of human cancer cells with Src-, Kras- or BRAF dependent activation of Erk1/2 , resistances to staurosporine or thapsigargin were also shown to depend on Bik degradation rate via a similar mechanism
Korman et al., Wiley interdisciplinary reviews. Systems biology and medicine 2013 (Melanoma) : Notably, combined therapies involving selective BRAF inhibitors ( SBIs ) and other inhibitors of MAPK dependent or MAPK independent resistance pathways appear particularly promising
Cho et al., Small GTPases 2013 (MAP Kinase Signaling System...) : BRaf inhibitors paradoxically activate CRaf and MAPK signaling in Ras transformed cells
King et al., PloS one 2013 : In addressing this issue, we showed that concomitant administration of BRAF and MEK inhibitors abrogated paradoxical BRAF inhibitor induced MAPK signalling in cells, reduced the occurrence of skin lesions in rats, and enhanced the inhibition of human tumor xenograft growth in mouse models
Denis-Henriot et al., Endocrinology 1998 : Wild-type Galpha12 overexpression prevented the decrease in MAPK activity and induced MEK1, but not B-Raf , expression