Gene interactions and pathways from curated databases and text-mining

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AKT1 — BRAF

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

Text-mined interactions from Literome

Guan et al., J Biol Chem 2000 : Negative regulation of the serine/threonine kinase B-Raf by Akt ... Furthermore, expression of Akt inhibits epidermal growth factor induced B-Raf activity and inhibition of Akt with LY294002 up-regulates B-Raf activity, suggesting that Akt negatively regulates B-Raf in vivo ... Furthermore, expression of Akt inhibits epidermal growth factor induced B-Raf activity and inhibition of Akt with LY294002 up-regulates B-Raf activity, suggesting that Akt negatively regulates B-Raf in vivo ... Our results demonstrate that B-Raf activity can be negatively regulated by Akt through phosphorylation in the amino-terminal regulatory domain of B-Raf
Zhang et al., J Biol Chem 2001 : We have recently reported that Akt negatively regulates B-Raf kinase activation by phosphorylating multiple residues within its amino-terminal regulatory domain ... These results indicate that B-Raf kinase activity is negatively regulated by Akt and SGK, suggesting that the cross-talk between the B-Raf and other signaling pathways can be mediated by both Akt and SGK
Brose et al., Cancer Res 2002 (Carcinoma, Non-Small-Cell Lung...) : Three BRAF mutations identified in this study are novel, altering residues important in AKT mediated BRAF phosphorylation and suggesting that disruption of AKT induced BRAF inhibition can play a role in malignant transformation
Yamaguchi et al., J Biol Chem 2004 (Polycystic Kidney Diseases) : Moreover, the activity of Akt , a negative regulator of B-Raf , was decreased by calcium restriction ... Inhibition of Akt or phosphatidylinositol 3-kinase also allowed cAMP dependent activation of B-Raf and ERK in normal calcium
Wallace et al., Biochim Biophys Acta 2011 (Calcium Signaling...) : In normal cells, B-Raf is repressed by Akt ( protein kinase B ), a Ca ( 2+ ) -dependent kinase, preventing cAMP activation of ERK and cell proliferation
Davies et al., Radiation oncology (London, England) 2011 (Rectal Neoplasms) : Downstream events from KRAS, such as activation of BRAF , AKT and ERK, may also confer prognostic information but have not been tested in rectal cancer ( RC )
Guo et al., J Pathol 2013 (Urinary Bladder Neoplasms) : A BRAF missense mutation G469V was found in HCV29 cells, and AKT activation was dependent on BRAF , but independent of ERK
Hong et al., Exp Cell Res 2013 (MAP Kinase Signaling System...) : AKT upregulates B-Raf Ser445 phosphorylation and ERK1/2 activation in prostate cancer cells in response to androgen depletion ... Using androgen deprived LNCaP cells, in which ERK1/2 activation occurs in strong correlation with AKT activation, we found that AKT mediated B-Raf regulation is necessary for ERK1/2 activation ... In contrast, AKT activity was sufficient to induce not only B-Raf phosphorylation but also MEK/ERK activation in the hormone refractory LNCaP variant, C4-2