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AKT1 — BRAF
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
-
IRef Biogrid Interaction:
AKT1
—
BRAF
(physical association, affinity chromatography technology)
Guan et al., J Biol Chem 2000*
-
IRef Biogrid Interaction:
AKT1
—
BRAF
(direct interaction, enzymatic study)
Guan et al., J Biol Chem 2000*
-
IRef Hprd Interaction:
AKT1
—
BRAF
(in vivo)
Guan et al., J Biol Chem 2000*, Zhang et al., J Biol Chem 2001*
-
IRef Hprd Interaction:
AKT1
—
BRAF
(in vitro)
Guan et al., J Biol Chem 2000*, Zhang et al., J Biol Chem 2001*
-
IRef Ophid Interaction:
AKT1
—
BRAF
(aggregation, interologs mapping)
Brown et al., Bioinformatics 2005
Text-mined interactions from Literome
Guan et al., J Biol Chem 2000
:
Negative
regulation of the serine/threonine kinase
B-Raf by
Akt ... Furthermore, expression of
Akt inhibits epidermal growth factor induced
B-Raf activity and inhibition of Akt with LY294002 up-regulates B-Raf activity, suggesting that Akt negatively regulates B-Raf in vivo ... Furthermore, expression of Akt inhibits epidermal growth factor induced B-Raf activity and inhibition of Akt with LY294002 up-regulates B-Raf activity, suggesting that
Akt negatively
regulates B-Raf in vivo ... Our results demonstrate that
B-Raf activity can be negatively
regulated by
Akt through phosphorylation in the amino-terminal regulatory domain of B-Raf
Zhang et al., J Biol Chem 2001
:
We have recently reported that
Akt negatively
regulates B-Raf kinase activation by phosphorylating multiple residues within its amino-terminal regulatory domain ... These results indicate that
B-Raf kinase activity is negatively
regulated by
Akt and SGK, suggesting that the cross-talk between the B-Raf and other signaling pathways can be mediated by both Akt and SGK
Brose et al., Cancer Res 2002
(Carcinoma, Non-Small-Cell Lung...) :
Three BRAF mutations identified in this study are novel, altering residues important in AKT mediated BRAF phosphorylation and suggesting that disruption of
AKT induced
BRAF inhibition can play a role in malignant transformation
Yamaguchi et al., J Biol Chem 2004
(Polycystic Kidney Diseases) :
Moreover, the activity of
Akt , a negative
regulator of
B-Raf , was decreased by calcium restriction ... Inhibition of
Akt or phosphatidylinositol 3-kinase also
allowed cAMP dependent activation of
B-Raf and ERK in normal calcium
Wallace et al., Biochim Biophys Acta 2011
(Calcium Signaling...) :
In normal cells,
B-Raf is
repressed by
Akt ( protein kinase B ), a Ca ( 2+ ) -dependent kinase, preventing cAMP activation of ERK and cell proliferation
Davies et al., Radiation oncology (London, England) 2011
(Rectal Neoplasms) :
Downstream events from KRAS, such as
activation of
BRAF ,
AKT and ERK, may also confer prognostic information but have not been tested in rectal cancer ( RC )
Guo et al., J Pathol 2013
(Urinary Bladder Neoplasms) :
A BRAF missense mutation G469V was found in HCV29 cells, and
AKT activation was
dependent on
BRAF , but independent of ERK
Hong et al., Exp Cell Res 2013
(MAP Kinase Signaling System...) :
AKT upregulates
B-Raf Ser445 phosphorylation and ERK1/2 activation in prostate cancer cells in response to androgen depletion ... Using androgen deprived LNCaP cells, in which ERK1/2 activation occurs in strong correlation with AKT activation, we found that
AKT mediated
B-Raf regulation is necessary for ERK1/2 activation ... In contrast,
AKT activity was
sufficient to induce not only
B-Raf phosphorylation but also MEK/ERK activation in the hormone refractory LNCaP variant, C4-2