Yang et al., Cancer Res 2004
(MAP Kinase Signaling System) :
API-2 is highly selective for Akt and does not inhibit the activation of phosphatidylinositol 3'-kinase, phosphoinositide dependent kinase-1, protein kinase C, serum- and glucocorticoid-inducible kinase, protein kinase A, signal transducer and activators of transcription 3, extracellular signal regulated kinase-1/2 , or c-Jun NH ( 2 ) -terminal kinase
Varfolomeev et al., Science signaling 2012
:
We demonstrated that c-IAP1 and c-IAP2 were required for canonical activation of NF-?B and MAPK by members of the TNFR family