Gene interactions and pathways from curated databases and text-mining

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BDNF — MAPK14

Text-mined interactions from Literome

Araki et al., J Neurochem 2000 : In contrast, the level of BDNF induced phosphorylation of mitogen activated protein kinase and coprecipitated proteins with anti-Trk and Grb2 antibodies did not show any difference between neurons infected with these two types of Shp-2 ... In addition, the phosphatase Shp-2 may not influence the level of BDNF induced activation of mitogen activated protein kinase in cultured cortical neurons
Jovanovic et al., Nat Neurosci 2000 (MAP Kinase Signaling System...) : In a synaptosomal preparation, brain derived neurotrophic factor (BDNF) increased mitogen activated protein ( MAP ) kinase dependent synapsin I phosphorylation and acutely facilitated evoked glutamate release
Pizzorusso et al., J Neurosci 2000 : Finally, BDNF caused phosphorylation of mitogen activated protein kinase ( MAPK ), and because the treatment with the MAPK inhibitor U0126 completely abolished CREB activation and c-fos upregulation, it is likely that both processes depend mainly on the MAP kinase pathway
Araki et al., J Neurochem 2000 : BDNF induced activation of mitogen activated protein kinase was not altered by the expression of these proteins
Obrietan et al., J Neurophysiol 2002 : Excitatory actions of GABA increase BDNF expression via a MAPK-CREB dependent mechanism -- a positive feedback circuit in developing neurons
Yamagishi et al., Brain Res Mol Brain Res 2003 (Potassium Deficiency) : Comparison of inhibitory effects of brain derived neurotrophic factor and insulin-like growth factor on low potassium induced apoptosis and activation of p38 MAPK and c-Jun in cultured cerebellar granule neurons
Alder et al., J Neurosci 2003 : BDNF mediated gene expression was tyrosine kinase B and mitogen activated protein kinase dependent , as demonstrated by pharmacological studies
Ruiz-León et al., J Neurochem 2004 (Neuroblastoma) : Taken together, our results suggest that simultaneous activation of at least two signalling pathways, Ras/MAPK and PI3K/Akt, is necessary to mediate a full activation of the APP promoter by BDNF
Zheng et al., J Neurochem 2004 : Western blot analyses showed that both IGF-1 and BDNF induced the activation of the phosphatidylinositide 3 kinase (PI3)/Akt ( protein kinase B ) kinase and the mitogen activated protein kinase ( MAPK ) pathways
Obata et al., Neuroscience 2004 (Pain...) : Therefore, we suggest that after inflammation near the cell body, NGF synthesized within the nerve root and DRG induces BDNF expression through trkA receptors and intracellular ERK-MAPK
Matsumoto et al., Mol Cell Neurosci 2006 : PLC-gamma inhibitor attenuated BDNF stimulated long lasting MAPK activation
Easton et al., J Neurochem 2006 (Neuroblastoma) : Characterization and kinetic and spatial modeling of the signaling pathways underlying this prolonged MAPK activation by BDNF will be important in understanding the physiological role of BDNF in many complex systems in the nervous system ... In addition to Shc, fibroblast growth factor receptor substrate 2 (FRS2) is required for the BDNF induced activation of MAPK ... Shp2 is required for complete MAPK activation by BDNF , as expression of a dominant negative Shp2 in cells attenuates BDNF induced activation of MAPK
Trang et al., J Neurosci 2009 : P2X4-receptor mediated synthesis and release of brain derived neurotrophic factor in microglia is dependent on calcium and p38-mitogen activated protein kinase activation ... Furthermore, we find that the P2X4R evoked release and synthesis of BDNF are dependent on activation of p38-mitogen activated protein kinase ( MAPK )
Huang et al., J Biol Chem 2009 : Moreover, Hrs-sensitive TrkB-FL recycling plays a role in BDNF induced prolonged mitogen activated protein kinase ( MAPK ) activation
Zadran et al., J Neurosci 2010 : In neurons, MAPK is activated by both brain derived neurotrophic factor (BDNF) and EGF
Zhang et al., Theriogenology 2010 (MAP Kinase Signaling System) : In this study, we investigated ( using western blots ) the effects of BDNF on the phosphorylation of protein kinase B (PKB) and mitogen activated protein kinase ( MAPK ) in mouse oocytes and cumulus cells cultured in vitro ... Furthermore, BDNF increased phosphorylation of MAPK in oocytes at 16h of in vitro maturation ( P=0.0041 ), but K252a together with BDNF did not reduce phosphorylation of MAPK in the oocytes
Yin et al., J Neurochem 2010 : In this study, we report RanBPM is a novel TrkB interacting protein that contributes to BDNF induced MAPK and Akt activation together with neuronal morphogenesis and survival ... Over-expression of RanBPM in PC1210 cells ( PC12 cells stably over expressing TrkB ) can significantly enhance BDNF induced MAPK and Akt activation
Bałkowiec-Iskra et al., Neuroscience 2011 (Inflammation) : The effect of TNFa on BDNF expression is dependent on sodium influx through TTX-sensitive channels and on p38-mitogen activated protein kinase
Bi et al., J Neurophysiol 2011 : Conversely, BDNF had no effect on subsequently applied ephrin-A5-Fc or EphA5-Fc. Consistent with this, ephrin-A5-Fc also prevented BDNF induced activation of p42/44 MAPK
Niu et al., J Neuropathol Exp Neurol 2011 : Our results indicate that BDNF increases telomerase expression and activity levels in SMNs and activates mitogen activated protein kinase/extracellular signal regulated kinases 1 and 2 and phosphatidylinositol-3-OH kinase/protein kinase B signals, and their downstream transcription factors nuclear factor-?B, c-Myc, and Sp1
Zhang et al., Behav Brain Res 2012 (Disease Models, Animal...) : Curcumin produces antidepressant effects via activating MAPK/ERK dependent brain derived neurotrophic factor expression in the amygdala of mice
Deogracias et al., Proc Natl Acad Sci U S A 2012 (Disease Models, Animal...) : Ongoing synaptic activity and MAPK signaling is required for fingolimod induced BDNF increase, a pathway that can also be activated in vivo by systemic fingolimod administration
Numakawa et al., Neuroscience 2013 : In CNS neurons, BDNF triggers activation of phospholipase C? ( PLC? ), mitogen activated protein/extracellular signal regulated kinase ( MAPK/ERK ), and phosphoinositide 3-kinase (PI3K)/Akt pathways, influencing neuronal cells beneficially through these intracellular signaling cascades
Roback et al., Eur J Neurosci 1995 : BDNF produced an increase in mitogen activated protein ( MAP ) kinase tyrosine phosphorylation, MAP kinase activity, intracellular calcium concentration and c-fos expression in the glial cells