UCSC Genome Browser Gene Interaction Graph

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Gene interactions and pathways from curated databases and text-mining

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BCL2L11 — SIRT1

Pathways - manually collected, often from reviews:

NCI Pathway Database FoxO family signaling: FOXO3A/SIRT1 complex (FOXO3-SIRT1) → BIM (BCL2L11) (transcription, inhibits) Dijkers et al., Curr Biol 2000 *, Brunet et al., Science 2004, Lehtinen et al., Cell 2006
Evidence: mutant phenotype, reporter gene