Gene interactions and pathways from curated databases and text-mining

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BCL2 — PRKAR2A

Pathways - manually collected, often from reviews:

Text-mined interactions from Literome

Chin et al., Exp Mol Med 2005 (Neoplasms) : We also revealed that the combined treatment of radiation and the inhibitor of protein kinase A (PKA) to these radioresistant cells resulted in synergistic inhibition of DNA-PK, Rad51 and Bcl-2 expressions of the cells, and consequently restored radiosensitivity of the cells
O'Driscoll et al., J Neurochem 2007 : Activation of the transcription factor cAMP-response element binding protein ( CREB ) and subsequent up-regulation of Bcl-2 in response to bFGF was also dependent on PKA as inhibition with H-89 attenuated increased pCREB levels and Bcl-2 expression ... These results indicate that the protective efficacy of bFGF in mouse photoreceptors involves PKA dependent inactivation of GSK3beta and subsequent up-regulation of Bcl-2 via CREB activation
Itano et al., J Neurochem 1996 (Neuroblastoma) : From these results, we suggest that the expression of Bcl-2 proteins is regulated by PKC and PKA in positive and negative manners, respectively, in SH-SY5Y cells
Srivastava et al., Mol Cell Biol 1998 (Breast Neoplasms...) : In addition, paclitaxel- and vincristine induced activation of cyclic AMP ( cAMP ) -dependent protein kinase ( protein kinase A [PKA ] ) induced Bcl2 hyperphosphorylation and apoptosis, which were blocked by the PKA inhibitor Rp diastereomers of cAMP ( Rp-cAMP )
Venkataraman et al., Mol Immunol 1998 : PKA-activation caused a downregulation of anti-IgM induced expression of Bcl-xL protein, that was restored by IL-4